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Solubility Enhancement
Fast In Vitro Release and In Vivo Absorption of an Anti-Schizophrenic Drug Paliperidone from Its…
The purpose of this study was to develop a drug delivery system for paliperidone (PPD) in order to provide a more effective therapeutic strategy for patients with acute schizophrenia. PPD-loaded Soluplus®/TPGS mixed micelles (PPD-S/T-MM) were prepared using the thin-film hydration method. The…
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Development and Characterization of Eudragit® EPO-Based Solid Dispersion of Rosuvastatin Calcium to…
Poor solubility is the major challenge involved in the formulation development of new chemical entities (NCEs), as more than 40% of NCEs are practically insoluble in water. Solid dispersion (SD) is a promising technology for improving dissolution and, thereby, the bioavailability of poorly soluble…
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Hydrogel-forming microarray patches with cyclodextrin drug reservoirs to enhance the long-acting…
The 12th APV PBP World Meeting took place from 28 – 31 March 2022 in Rotterdam. There was a poster section at the event where really interesting scientific posters were presented. Therefore we asked the presenting scientists if we could share their work in addition online with the Pharma Excipients…
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Comparative bioavailability study following a single dose intravenous and buccal administration of…
As remdesivir, the first FDA-approved drug for SARS-CoV-2 infection, can be used only for hospitalized patients due to intravenous administration, there is an urgent need of effective oral antiviral formulations to be used at early stage of infection in an outpatient setting. The present paper…
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Using natural excipients to enhance the solubility of the poorly water-soluble antiretroviral,…
The anti-retroviral drug efavirenz (EFV) exhibits poor aqueous solubility which renders pharmaceutical formulation challenging. During a pre-formulation phase, involving spray drying of EFV for pediatric dosage form development, the combination of EFV with two natural excipients, pea protein isolate…
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Dabigatran Formulation for Oral Administration – an Evaluation
Dabigatran etexilate mesylate is a pro-drug of Dabigatran – a BSC Class II drug used as anti-coagulant in deep vein thrombosis as a direct thrombin inhibitor. Due to increasing solubility in the acidic regime, tartaric acid pellets (TAP) are used as starter beads. A processed formulation is compared…
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Influence of amino acids on the aggregation behavior and drug solubilization of branched block…
Block copolymers and their related structure-performance relationships for controllable drug delivery have gained much attention recently. In this work, multibranched PEO-PPO copolymer M904 was synthesized, which had the same PEO and PPO segments with commercial 4-branched copolymer Tetronic 904…
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Investigation on in-vitro Dissolution and Tableting Properties Enhancement of Etodolac using…
Objectives: The objective of present study was to improve dissolution rate with tableting properties of BCS class II drug Etodolac, by melt granulation and sublimation techniques.
Materials and Methods: The granules of etodolac were formulated using Gelucire 50/13. The surface adsorbent Aerosil…
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The Developability Classification System (DCS): Enabling an Optimized Approach for Formulation of…
Ensuring sufficient solubility for orally delivered solid dosage forms is a critical step in their development. Most, if not all, of the absorption of these dosage forms takes place in the small intestine, where the drug must be sufficiently dissolved in the gastrointestinal fluids to pass through…
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Apinovex™ Polymers – Solubility-Enhancing Excipients for Amorphous Solid Dispersions
Lubrizol’s Apinovex™ polymers are high molecular weight polyacrylic acid excipients designed to provide both processing and formulation benefits for spray-dried amorphous solid dispersions (ASDs).
Apinovex polymers enable formulators to enhance the solubility of BCS Class II and IV APIs and…
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