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Solubility Enhancement
Design and molecular insights of drug-active metabolite based co-amorphous formulation: A case study…
Co-amorphous supersaturated drug delivery systems are emerging as an alternative strategy to improve the water solubility of BCS II drugs. Typically, the supersaturation and stability of co-amorphous systems largely depend on the type of employed co-former. This study aims to assess the potential…
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Improved solubility of lornoxicam by inclusion into SBA-15: Comparison of loading methods
An increasing proportion of new medicinal substances are poorly soluble in water. Adsorption on mesoporous silicas increases their bioavailability when administered orally. Loading method determines adsorption either on the surface in crystalline state or inside the mesopores in amorphous form. The…
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Tablet Disintegration and Dispersion under In Vivo-like Hydrodynamic Conditions
Disintegration and dispersion are functional properties of tablets relevant for the desired API release. The standard disintegration test (SDT) described in different pharmacopoeias provides only limited information on these complex processes. It is considered not to be comparable to the biorelevant…
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Hot-melt extruded hydroxypropyl methylcellulose acetate succinate based amorphous solid dispersions:…
Nucleation inhibition and maintenance of drug supersaturation over a prolonged period are desirable for improving oral absorption of amorphous solid dispersions. The present study investigates the impact of binary and ternary amorphous solid dispersions on the supersaturation kinetics of nifedipine…
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Development and evaluation of nano-formulations for immediate release oral dosage forms of poorly…
Inaugural-Dissertation to obtain the academic degree Doctor rerum naturalium (Dr. rer. nat.) submitted to the Department of Biology, Chemistry, Pharmacy of Freie Universität Berlin by Zun Huang
Solubility and dissolution rate are essential for the oral absorption and thus bioavailability of…
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Apinovex™ Polymers – the Key to Addressing Solubility Challenges in Oral Formulations
Between 40-70% of marketed drugs and up to 90% of all new chemical entities (NCEs) suffer from poor water solubility, meaning they don’t readily dissolve in an aqueous solution. This has significant negative consequences for the bioavailability of the active pharmaceutical ingredient (API), with an…
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Effect of Soluplus® on γ-cyclodextrin solubilization of irbesartan and candesartan and their…
The poor aqueous solubility of irbesartan (IRB) and candesartan cilexetil (CAC) may hamper their bioavailability when orally or topically administered. Among several attempts, the promising nanoaggregate formation by γ-cyclodextrin (γCD) complexation of drugs in aqueous solution with or without…
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Ball milling and hot-melt extrusion of indomethacin–L-arginine–vinylpyrrolidone-vinyl acetate…
Commonly applied approaches to enhance the dissolution properties of low water-soluble crystalline active pharmaceutical ingredients (APIs) include their amorphization by incorporation into a polymeric matrix and the formation of amorphous solid dispersions (ASDs), or blending APIs with…
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Smart design approaches for orally administered lipophilic prodrugs to promote lymphatic transport
Challenges to effective delivery of drugs following oral administration has attracted growing interest over recent decades. Small molecule drugs (<1000 Da) are generally absorbed across the gastrointestinal tract into the portal blood and further transported to the systemic circulation via the…
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Understanding the self-assembly of the polymeric drug solubilizer Soluplus®
Soluplus® is one of the most widely used amphiphilic copolymers in drug delivery and has been reported to strongly enhance the adsorption of model drugs. However, there is still a limited understanding of its micellar behavior as it responds to the different routes of administration, which involve…
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