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Solubility Enhancement
Improved Bioavailability of Poorly Water-Soluble Drug by Targeting Increased Absorption through…
Itraconazole (ITZ) is a class II drug according to the biopharmaceutical classification system. Its solubility is pH 3-dependent, and it is poorly water-soluble. Its pKa is 3.7, which makes it a weak base drug. The aim of this study was to prepare solid dispersion (SD) pellets to enhance the release…
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Determination of Paclitaxel Solubility and Stability in the Presence of Injectable Excipients
Due to poor aqueous solubility of paclitaxel, cremophor is one of the excipients used to improve solubility in Taxol while it is responsible for a number of adverse effects such as anaphylactic shock. This research was aimed to determine the solubility and stability of paclitaxel in the presence of…
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Application of Insoluble Excipients in Solid Dispersion of Chinese Medicines
In recent years, as the great success of arteannuin in the area of antimalarial treatment and commercial benefit, traditional Chinese medicine (TCM) has received great attention. However, most of the active pharmaceutical ingredients (API) of Chinese medicines are hydrophobic, which causes the low…
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Development of fast-dissolving dosage forms of curcuminoids by electrospinning for potential tumor…
Curcuminoids (CUs) of antitumor and various other potential biological activities have extremely low water solubility therefore special formulation was elaborated. New fast dissolving reconstitution dosage forms of four CUs were prepared as fibrous form of 2-hydroxypropyl-β-cyclodextin (HP-β-CD). In…
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Application of TPGS as an efflux inhibitor and a plasticizer in baicalein solid dispersion
The oral bioavailability and efficacy of baicalein is dramatically limited by its low solubility and effect of efflux. In our study, we chose PVP-VA64 as a carrier and TPGS as a plasticizer and efflux inhibitor to prepare a solid dispersion of baicalein using hot-melt extrusion technology to improve…
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Cellulosic Polymers for Enhancing Drug Bioavailability in Ocular Drug Delivery Systems
One of the major impediments to drug development is low aqueous solubility and thus poor bioavailability, which leads to insufficient clinical utility. Around 70–80% of drugs in the discovery pipeline are suffering from poor aqueous solubility and poor bioavailability, which is a major challenge…
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Combined Use of Cyclodextrins and Amino Acids for the Development of Cefixime Oral Solutions for…
Cefixime (CEF) is a cephalosporin included in the WHO Model List of Essential Medicines for Children. Liquid formulations are considered the best choice for pediatric use, due to their great ease of administration and dose-adaptability. Owing to its very low aqueous solubility and poor stability,…
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Application of TPGS as an efflux inhibitor and a plasticizer in baicalein solid dispersion
The oral bioavailability and efficacy of baicalein is dramatically limited by its low solubility and effect of efflux. In our study, we chose PVP-VA 64 as a carrier and TPGS as a plasticizer and efflux inhibitor to prepare a solid dispersion of baicalein using hot-melt extrusion technology to…
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Design and Characterization of HY-038 Solid Dispersions via Spray Drying Technology
The aim of this study was to prepare HY-038 solid dispersions (SDs) with single carrier at high drug loading and then forming a tablet to enhance solubility, dissolution, and bioavailability via spray drying technology. At the same time, we hope to develop a more convenient in vitromethod to predict…
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Emulsion-electrospun polyvinyl alcohol nanofibers as a solid dispersion system to improve solubility…
We attempted to improve the solubility of poorly water-soluble drugs by preparing drug-loaded polyvinyl alcohol (PVA) nanofibers as a solid dispersion system via emulsion electrospinning. Probucol (PBC), a poorly water-soluble drug, was used as a model drug. Nanofibers were electrospun using an…
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