Browsing Category
Solubility Enhancement
Lipid Nanoparticles Loaded with Farnesol or Geraniol to Enhance the Susceptibility of E. coli MCR-1…
Resistance to colistin, one of the antibiotics of last resort against multidrug-resistant Gram-negative bacteria, is increasingly reported. Notably, MCR plasmids discovered in 2015 have now been reported worldwide in humans. To keep this antibiotic of last resort efficient, a way to tackle this…
Read More...
Read More...
Formulation of ternary genistein β-cyclodextrin inclusion complex: In vitro characterization and…
Genistein (GT) is a poorly water-soluble flavonoid and reported for different biological activity. The present work was designed to prepare the inclusion complex using β-Cyclodextrins (β-CDs) as complexing agent and D -α-Tocopherol polyethylene glycol 1000 succinate (TPGS) as ternary substance to…
Read More...
Read More...
Impact of co-administered stabilizers on the biopharmaceutical performance of regorafenib amorphous…
Poor solubility of drug candidates is a well-known and thoroughly studied challenge in the development of oral dosage forms. One important approach to tackle this challenge is the formulation as an amorphous solid dispersion (ASD). To reach the desired biopharmaceutical improvement a high…
Read More...
Read More...
Impact of Simulated Intestinal Fluids on Dissolution, Solution Chemistry, and Membrane Transport of…
The solution behavior and membrane transport of multidrug formulations were herein investigated in a biorelevant medium simulating fasted conditions. Amorphous multidrug formulations were prepared by the solvent evaporation method. Combinations of atazanavir (ATV) and ritonavir (RTV) and felodipine…
Read More...
Read More...
Stability, pharmacokinetics, and biodistribution in mice of the EPAC1 inhibitor (R)-CE3F4 entrapped…
(R)-CE3F4, a specific inhibitor of EPAC1 (exchange protein directly activated by cAMP type 1), has been demonstrated in vitro and in vivo to reduce hypertrophic signaling contributing to heart failure or to control arrhythmia and has shown promise as a drug candidate. However, (R)-CE3F4 exhibits…
Read More...
Read More...
UNGAP best practice for improving solubility data quality of orally administered drugs
An important goal of the European Cooperation in Science and Technology (COST) Action UNGAP (UNderstanding Gastrointestinal Absorption-related Processes, www.ungap.eu) is to improve standardization of methods relating to the study of oral drug absorption. Solubility is a general term that refers to…
Read More...
Read More...
Amorphous Solid Dispersions (ASDs): The Influence of Material Properties, Manufacturing Processes…
Poorly water-soluble drugs pose a significant challenge to developability due to poor oral absorption leading to poor bioavailability. Several approaches exist that improve the oral absorption of such compounds by enhancing the aqueous solubility and/or dissolution rate of the drug. These include…
Read More...
Read More...
Insights into the Solubility and Structural Features of Four Praziquantel Cocrystals
Cocrystal technology can effectively improve the solubility and other physicochemical properties of compounds. The structural features of cocrystals are the key factors that affect the physicochemical properties. The present study aimed to investigate the solubility of the cocrystals formed between…
Read More...
Read More...
Solubility: Definition and explanation by Pharma Drama
It's probably the most important physicochemical property of a drug, but what actually is solubility? Pharma Drama is here to give you the solution! In this Snug, we look at the basics of solubility - how it's defined and how it's measured.
Watch the video here:…
Read More...
Read More...
Investigating the Critical Variables of Azithromycin Oral Absorption Using In Vitro Tests and PBPK…
Azithromycin is an antibiotic listed in the essential list of medicines for adults and pediatrics. Conflicting evidence has been found regarding azithromycin classification according to the Biopharmaceutics classification system (BCS). The purpose of this study was to identify the critical variables…
Read More...
Read More...