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Solubility Enhancement
Preparation and Characterization of Ibrutinib Amorphous Solid Dispersions: a Discussion of…
The aim of this study was to improve the solubility and dissolution of Ibrutinib (IBR), a biopharmaceutical classification system (BCS) class II drug, by preparing binary and ternary amorphous solid dispersions (ASDs). The physicochemical properties of the ASD formulations were evaluated.…
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Enhance the solubility of poorly soluble drugs with AFFINISOL™
Looking to enhance the solubility of poorly soluble drugs?
Consider AFFINISOL™, a water-soluble polymer that optimizes solubility enhancement by maintaining stable solid dispersions and inhibiting API crystallization.
It’s been specifically designed for generating solid dispersions via…
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Study of solid-state transitions and its impact on solubility and stability of Repaglinide
The aim of this research was to study the impact of melting and quenching approach on solid-state characteristics of amorphous dispersion and its impact on dissolution and solubility of Repaglinide, a BCS Class II drug. Solid dispersions of Repaglinide were prepared separately by quench cooling…
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TPGS-Modified Long-Circulating Liposomes Loading Ziyuglycoside I for Enhanced Therapy of…
Background: Ziyuglycoside I (ZgI), an active ingredient isolated from traditional Chinese medicine Sanguisorba officinalis L, has been demonstrated to increase the leucocytes and protect hematopoietic stem cells. However, the poor solubility and a short half-life of ZgI limit its bioavailability and…
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Solid Dispersion Product Families
The right solution for your formulation challenges
Equipped with an in-depth understanding of multiple industries, technologies and applications, BASF has the skills and resources to make drug manufacturing more efficient, robust, and cost-effective.
Whether you want to make your medicine more…
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Eudragit®: A Versatile Family of Polymers for Hot Melt Extrusion and 3D Printing Processes in…
Eudragit® polymers are polymethacrylates highly used in pharmaceutics for the development of modified drug delivery systems. They are widely known due to their versatility with regards to chemical composition, solubility, and swelling properties. Moreover, Eudragit polymers are thermoplastic, and…
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Ionic Liquid-Based Catanionic Vesicles: A De Novo System to Judiciously Improve the Solubility,…
Highlights
• Ester functionalized surface active ionic liquids were synthesized.
• Biodegradable and biocompatible catanionic vesicles were prepared.
• Analytical techniques were used to study the structure of catanionic vesicles.
• Small angle neutron scattering was used to…
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Chrono modulated multiple unit particulate systems (MUPS) via a continuous hot melt double extrusion…
The current study is aimed at the development of chrono modulated multiple unit particulate systems (MUPS) of nifedipine (ND) by a continuous double extrusion process. ND, a poorly soluble drug, was formulated into an amorphous solid dispersion (ASD) to improve its solubility. Further, the ASD was…
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Processing Impact on In Vitro and In Vivo Performance of Solid Dispersions—A Comparison between…
Presently, a large number of drug molecules in development are BCS class II or IV compounds with poor aqueous solubility. Various novel solubilization techniques have been used to enhance drug solubility. Among them, amorphous solid dispersions (ASD), which convert a crystalline drug into an…
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Cellulose derivatives as effective recrystallization inhibitor for ternary ritonavir solid…
Amorphous solid dispersions (ASDs) are regarded as one of the most promising techniques for poorly-soluble active pharmaceutical ingredients (API). However, the thermodynamic instability of ASDs at supersaturated state makes them easy to recrystallize in aqueous media.
In this study, ritonavir…
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