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Solubility Enhancement
What Are the Important Factors That Influence API Crystallization in Miscible Amorphous…
In this perspective, the authors examine the various factors that should be considered when attempting to use miscible amorphous API–excipient mixtures (amorphous solid dispersions and coamorphous systems) to prevent the solid-state crystallization of API molecules when isothermally stored for long…
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Solvent mixtures in pharmaceutical development: Maximizing the API solubility and avoiding phase…
Knowing the solubilities of active pharmaceutical ingredients (APIs) in pure solvents and solvent mixtures is essential for several manufacturing aspects of pharmaceutical product development. In this paper, we demonstrate that time-consuming and costly experiments can be reduced to a minimum using…
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Self-Assembling Dioscorea bulbifera loaded mixed micelles: Formulation optimization, in-vitro…
Dioscorea bulbifera (DB)is one among the traditionally used medicinal plant which has been reported to have anticancer property and capable of inducing apoptosis of tumors, but the poor water solubility restricts its pharmacological application. The study aims at improving the aqueous solubility of …
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Hot punching for loading of biodegradable microcontainers with budesonide-Soluplus film
Micro-reservoir based drug delivery systems have the potential to provide targeted drug release locally in the intestine, i.e. at the inflamed areas of the intestine of patients with inflammatory bowel disease (IBD). In this study, microcontainers with a diameter of 300 µm and a height of 100 µm,…
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Effect of pH modifiers on the solubility, dissolution rate, and stability of telmisartan solid…
The aim of the current study was to investigate the dual effect of an amorphous solid dispersion generated by hot melt extrusion and the addition of pH modifiers on the solubility and stability of telmisartan. Hydroxypropyl methylcellulose acetate succinate L grade was used as a polymeric carrier…
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A Trusted Solutions Provider To Adress Poor Drug Solubility
THE DRUG SOLUBILITY SPECIALIST FOR SOLID DISPERSIONS, PARTICLE ENGINEERING AND SILICA TECHNOLOGIES
Almost half of currently marketed drug products, and around 90 % of those in clinical development are associated with poor drug solubility or permeability. A multitude of factors can affect drug…
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Development of a BCS Class II Drug Microemulsion for Oral Delivery: Design, Optimization, and…
Our work is aimed at exploring the composition and the properties of microemulsion (ME), as a drug delivery system, to enhance the permeability across the gastrointestinal (GI) barrier of fenofibrate, a BCS class II drug. It is a prodrug that is converted rapidly after oral administration into a…
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Tetrahydrocurcumin encapsulation in cyclodextrins for water solubility improvement: synthesis,…
The solubility of the scarcely water-soluble molecule tetrahydrocurcumin (THC), a promising curcumin derivative to be used as biopesticide, was enhanced through the formation of inclusion complexes with different cyclodextrins (CDs). Randomly methylated β-cyclodextrin (MeβCD) gave the best results…
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Formulation of Chewable Tablets Containing Carbamazepine-β-cyclodextrin Inclusion Complex and F-Melt…
Due to its low solubility, carbamazepine (CBZ) exhibits slow and incomplete release in the gastrointestinal tract and, hence, variable pharmacokinetics and pharmacodynamic effect. Lots of methods have been devised to improve its solubility, the large number of proposed solutions being a sign that…
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The Influence of Drug–Polymer Solubility on Laser-Induced In Situ Drug Amorphization Using…
In this study, laser-induced in situ amorphization (i.e., amorphization inside the final dosage form) of the model drug celecoxib (CCX) with six different polymers was investigated. The drug–polymer combinations were studied with regard to the influence of (i) the physicochemical properties of the…
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