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Solubility Enhancement
Solubility Enhancement of Diclofenac Using Solid Dispersions
The phenomenon which gives rise to a homogenous system, formed by the dissolution of solute in a solvent is known as solubility. Low solubility is the limiting factor in formulation development. Diclofenac being BCS class II drug have low aqueous solubility of 0.00401mg/ml. Amongst various…
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Solid Dispersion as a Technical Solution to Boost the Dissolution Rate and Bioavailability of Poorly…
Solid dispersion (SD) is one of the oldest and widely utilized techniques to improve the solubility of slowly dissolving drugs. A variety of pharmaceutically compatible additives using different emerging technology is used for preparing SDs. Multiple approaches were designed to prepare SDs by such…
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Hot-Melt Extrusion: a Roadmap for Product Development
Hot-melt extrusion has found extensive application as a feasible pharmaceutical technological option over recent years. HME applications include solubility enhancement, taste masking, and sustained drug release. As bioavailability enhancement is a hot topic of today’s science, one of the main…
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ZoomLab™: Digitally guiding dosage form and formulation for improved solubility
Poorly soluble drugs for oral administration present unique formulation challenges, particularly during early development. Various formulation approaches are available, and several aspects must be evaluated in order to identify which choice is most suitable for a specific drug.
BASF has developed…
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Pharmaceutical amorphous solid dispersion: A review of manufacturing strategies
Amorphous solid dispersions (ASDs) are popular for enhancing the solubility and bioavailability of poorly water-soluble drugs. Various approaches have been employed to produce ASDs and novel techniques are emerging. This review provides an updated overview of manufacturing techniques for preparing…
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Amorphous Solid Dispersions Containing Residual Crystallinity: Competition Between Dissolution and…
Crystallinity in an amorphous solid dispersion (ASD) may negatively impact dissolution performance by causing lost solubility advantage and/or seeding crystal growth leading to desupersaturation. The goal of the study was to evaluate underlying dissolution and crystallization mechanisms resulting…
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Hot-melt extrusion: Highlighting recent advances in pharmaceutical applications
Hot-melt extrusion (HME) has emerged as a pioneering manufacturing technology for pharmaceutical industries, and the utilization is overgrowing due to its unit operation, cost-effectiveness, solvent-free nature, and continuous manufacturing as compared to conventional techniques. Prime importance…
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Decision Support for Solubilization is now available in ZoomLab™
If you are working with poorly water-soluble APIs and wondering about effective formulation strategies - this 2.4 version update to ZoomLab™ by BASF is truly revolutionary.
Calculate Hansen SOL parameters for any APIs
Discover formulation strategy recommendations
Search similar drug…
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Exploring novel carrier for improving bioavailability of Itraconazole: Solid dispersion through…
Kollicoat® Smartseal (Methyl methacrylate and diethylaminoethyl methacrylate copolymer dispersion) which is used for taste masking and moisture protection, has shown the ability for forming solid dispersion. The present study aimed to check its feasibility for improvement of pharmacokinetics when…
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Development of Apremilast Solid Dispersion Using TPGS and PVPVA with Enhanced Solubility and…
Apremilast (APST) is an effective inhibitor of phosphodieasterase 4 (PDE4) which is the first oral drug for the treatment of adult patients with active psoriatic arthritis. However, Apremilast’s low solubility restricts its dissolution and bioavailability. In this study, APST solid dispersion with…
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