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Solubility Enhancement
Enhance API solubility. Achieve stable, high drug loads – with Parteck® MXP
Poor solubility of APIs is a critical challenge in drug development. One formulation technique to increase solubility and, consequently, improve bioavailability of drugs is hot melt extrusion (HME). With this technology, the API is dispersed into a polymer matrix to form an amorphous solid…
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Exploring novel carrier for improving bioavailability of Itraconazole; Solid dispersion through Hot…
Kollicoat® Smartseal (Methyl methacrylate and diethylaminoethyl methacrylate copolymer dispersion) which is used for taste masking and moisture protection, has shown the ability for forming solid dispersion. The present study aimed to check its feasibility for exhibit improved pharmacokinetics when…
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Enhancement of oral bioavailability and anti-hyperuricemic activity of aloe emodin via novel…
The objective of this study was to fabricate a novel drug delivery system using Soluplus® (polyvinyl caprolactam–polyvinyl acetate–polyethylene glycol graft copolymer) and glycyrrhizic acid to improve solubility, bioavailability, and anti-hyperuricemic activity of aloe emodin (AE). The AE-loaded…
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Sulfobutylether-beta-cyclodextrin-enabled antiviral remdesivir: Characterization of electrospun- and…
Veklury™ by Gilead Sciences, Inc., containing antiviral drug, remdesivir (REM) has received emergency authorization in the USA and in Europe for COVID-19 therapy. Here, for the first time, we describe details of the non-covalent, host-guest type interaction between REM and the solubilizing…
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Design, Development, and Evaluation of Controlled Release Tablets of Nateglinide Solid Dispersions
The current study deals with formulation and evaluation of nateglinide solid dispersion (SD) incorporate into tablet formulation for controlled release of the drug.
Methods: The nateglinide SD prepared using crospovidone and evaluated for drug content and drug dissolution. The optimized…
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Design and characterisation of an amorphous formulation of nifedipine for the treatment of autonomic…
Current treatment for autonomic dysreflexia (AD) involves rupturing a liquid-filled soft capsule of nifedipine to aid rapid drug release and absorption, however, this application is not covered under the manufacturer's license. The objective of the current work was to design a rapidly dissolving…
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Evaluation and Comparison of Solid Lipid Nanoparticles (SLNs) and Nanostructured Lipid Carriers…
The aim of this study was the optimization of solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC) in terms of physicochemical and biopharmaceutical properties, to develop effective and stable aqueous liquid formulations of hydrochlorothiazide, suitable for paediatric therapy,…
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Understanding the Synergistic Correlation between the Spatial Distribution of Drug-Loaded Mixed…
To better promote the application of polymeric mixed micelles (PMMs), a coarse-grained molecular dynamics simulation (CGMD) has been employed to investigate the factors controlling the spatial distribution within the PMMs and predict their drug-loading properties, meanwhile, combined with…
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Optimized semisolid self-nanoemulsifying system based on glyceryl behenate: A potential nanoplatform…
Raloxifene hydrochloride (RLX) is a selective estrogen receptor modulator used for treatment and protection against postmenopausal osteoporosis. The drug has been used for protection against breast cancer and more recently, for management of the disease by virtue of its estrogen antagonist action.…
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Formulation and Optimization of Atovaquone Micronized Suspension by Top-down Method
Aim: The present work aimed to tackle the solubility issue of a Biopharmaceutics Classification System (BCS) II drug, Atovaquone.
Methods: Formulation of micronized suspension of atovaquone was optimized by employing a 32 full factorial design keeping poloxamer 188 (wetting agent) and…
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