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Solubility Enhancement
Influence of high pressure compaction on solubility and intrinsic dissolution of ibuprofen binary…
Enabling formulations often depend on functional excipients. However, the question remains whether excipients regarded as standard establish similar interactions and subsequently improvement of solubility when employed at unusual manufacturing process conditions.
In this study, compaction of API…
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A meticulous overview on drying-based (spray-, freeze-, and spray-freeze) particle engineering…
Drying is an indispensable operation in the preparation of pharmaceutical powders and always remained one of the energetic tasks in the pharmaceutical industry. Improving the stability, solubility, and dissolution of pharmaceutical products are being prime objectives of the drying process, intending…
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Improved Dissolution Rate and Intestinal Absorption of Fexofenadine Hydrochloride by the Preparation…
The objective of this study was to enhance dissolution and permeation of a low soluble, absorbable fexofenadine hydrochloride (FFH) by preparing solid dispersions using polyethylene glycol 20,000 (PEG 20,000) and poloxamer 188 as carriers. The phase solubility measurement for the supplied FFH…
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Particle Forming Amorphous Solid Dispersions: A Mechanistic Randomized Pharmacokinetic Study in…
Amorphous solid dispersions (ASDs) are a promising drug-delivery strategy to overcome poor solubility through formulation. Currently, the understanding of drug absorption mechanisms from ASDs in humans is incomplete. Aiming to gain insights in this matter, we conducted a randomized cross-over design…
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The Development and Optimization of Hot-Melt Extruded Amorphous Solid Dispersions Containing…
Rivaroxaban (RXB), a novel oral anticoagulant that directly inhibits factor Xa, is a poorly soluble drug belonging to Biopharmaceutics Classification System (BCS) class II. In this study, a hot-melt extruded amorphous solid dispersion (HME-ASD) containing RXB is prepared by changing the drug:polymer…
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Effect of Carrier Type and Tween® 80 Concentration on the Release of Silymarin from Amorphous Solid…
Silymarin is a mixture of flavonolignans obtained from the seeds of milk thistle (Silybum marianum L. Gaertner). Silymarin behaves as a weak acid and is categorised as a class IV drug substance in accordance with biopharmaceutics drug disposition classification system, possessing low solubility, as…
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A One-Step Twin-Screw Melt Granulation with Gelucire 48/16 and Surface Adsorbent to Improve the…
Fenofibrate is an effective lipid-lowering drug; however, its poor solubility and high log p (5.2) result in insufficient absorption from the gastrointestinal tract, leading to poor bioavailability. In this study, a one-step continuous twin-screw melt granulation process was investigated to improve…
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Measuring Saturation Solubility in Lipid Excipients
Obtaining solubility data in a sufficiently broad range of lipid excipients is the first step towards the development of a lipid-based formulation. Solubility is an indication of expected drug load and performance of the formulation.
Solubility testing: part of the LBF development
A systematic…
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Self-Emulsifying Drug Delivery System: A Novel Approach for Oral Delivery of Poorly Water Soluble…
Self nano emulsifying drug delivery systems (SNEDDs) gained much attention in the last decades since, such systems considered one of the most favorable and efficient approaches to enhance solubility, increase drug absorption and hence, enhance its oral bioavailability of poorly water soluble…
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Improved Bioavailability and High Photostability of Methotrexate by Spray-Dried Surface-Attached…
Low aqueous solubility and poor bioavailability are major concerns in the development of oral solid-dosage drug forms. In this study, we fabricated surface-attached solid dispersion (SASD) to enhance the solubility, bioavailability, and photostability of methotrexate (MTX), a highly lipophilic and…
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