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Solubility Enhancement
In-Silico Screening of Lipid-Based Drug Delivery Systems
Purpose
This work proposes an in-silico screening method for identifying promising formulation candidates in complex lipid-based drug delivery systems (LBDDS).
Method
The approach is based on a minimum amount of experimental data for API solubilites in single excipients. Intermolecular…
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Development of orally disintegrating tablets containing solid dispersion of a poorly soluble drug…
Diacerein (DCN), a potent anti-inflammatory API used to treat osteoarthritis yet, it suffers from poor water solubility which affects its oral absorption. Unabsorbed colonic DCN is converted into rhein, which is responsible for laxation as a main side effect of DCN treatment. Therefore, in this…
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Organic Solution Advanced Spray-Dried Microparticulate/Nanoparticulate Dry Powders of Lactomorphin…
The purpose of this study was to formulate Lactomorphin (MMP2200) in its pure state as spray-dried(SD) powders, and with the excipient Trehalose as co-spray-dried(co-SD) powders; for intranasal and deep lung administration with Dry Powder Inhalers (DPI). Lactomorphin is a glycopeptide which was…
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A novel amorphous solid dispersion based on drug–polymer complexation
Rafoxanide (RAF) is a poorly water-soluble drug that forms a complex with povidone K25 (PVP) in a cosolvent system containing acetone and an alkaline aqueous medium. This study aims to investigate the impact of RAF-PVP complexation on in vitro and in vivo release of RAF. We prepared two RAF…
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Cocrystal Formulations: Evaluation of the Impact of Excipients on Dissolution by Molecular…
Cocrystallization has matured into an established technique for fine-tuning the physicochemical properties of active pharmaceutical ingredients (APIs). This technique has been adopted by pharmaceutical drug companies, with increasing numbers of cocrystal-based drug products now entering the market.…
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Solubility Enhancement of Drugs with Aid of Surfactants: Research Done Since Last Two Decades
This review aims to explore the past work done on the solubility enhancement of drugs using surfactants. Surfactants plays an important part in many routes of interest in both essential and practical science. The most vital function of surfactant is the formation of micelle in solution, which has…
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Leveraging bile solubilization of poorly water-soluble drugs by rational polymer selection
Poorly water-soluble drugs frequently solubilize into bile colloids and this natural mechanism is key for efficient bioavailability. We tested the impact of pharmaceutical polymers on this solubilization interplay using proton nuclear magnetic resonance spectroscopy, dynamic light scattering, and by…
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Vicissitudes of liquid crystals for solubility enhancement of poorly soluble drugs
A drug product should have aqueous solubility to avoid bioavailability issues. Low and erratic bioavailability is a problem encountered by almost 40–60% of new drug products coming out of research and development which are aimed to be delivered orally. This issue hampers their safety and efficacy as…
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Characterization of Sulfobutyl Ether Betacyclodextrin Binary and Ternary Inclusion Complexes of…
Background: Poor solubility and dissolution of drugs are major hindering factors in the development of their
oral dosage forms with acceptable bioavailability. Of the various approaches, employing amorphous form of
drugs is frequently utilized to develop drug products. Inclusion complexation is…
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Solubilization of tadalafil using a tartaric acid and chitosan-based multi-system
Solubilization studies of tadalafil (TDF) have recently improved the dissolution (%) using weak acids and bases in our group. However, the weak acid formulations have a low dissolution (%) of TDF as limitation. Thus, the purpose of this study was to improve the dissolution (%) of TDF over 90% in…
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