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Solubility Enhancement
Quality-by-design in hot melt extrusion based amorphous solid dispersions: An industrial perspective…
An industrially feasible approach to overcome the solubility and bioavailability limitations of poorly soluble active pharmaceutical ingredients is the development of amorphous solid dispersions (ASDs) using hot-melt extrusion (HME) technique. The application of Quality by Design (QbD) had a…
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Molecular Dynamics Simulations Reveal Membrane Interactions for Poorly Water-Soluble Drugs: Impact…
Molecular transport mechanisms of poorly soluble hydrophobic drug compounds to lipid membranes were investigated using molecular dynamics (MD) simulations. The model compound danazol was used to investigate the mechanism(s) by which bile micelles delivered it to the membrane.
The interactions…
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Self-Nanoemulsifying System Loaded with Sildenafil Citrate and Incorporated within Oral Lyophilized…
Sildenafil citrate is a drug used throughout the world primarily to treat erectile dysfunction. Several problems with the commercially available product decrease its efficacy, such as limited solubility, delayed onset of action, and low bioavailability with a large variability in the absorption…
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Overview of Extensively Employed Polymeric Carriers in Solid Dispersion Technology
Solid dispersion is the preferred technology to prepare efficacious forms of BCS class-II/IV APIs. To prepare solid dispersions, there exist a wide variety of polymeric carriers with interesting physicochemical and thermochemical characteristics available at the disposal of a formulation…
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Solubility and Stability Enhanced Oral Formulations for the Anti-Infective Corallopyronin A
Novel-antibiotics are urgently needed to combat an increase in morbidity and mortality due to resistant bacteria. The preclinical candidate corallopyronin A (CorA) is a potent antibiotic against Gram-positive and some Gram-negative pathogens for which a solid oral formulation was needed for further…
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The enhancement of the aqueous solubility of Albendazole employing polymeric amorphous solid…
PURPOSE
Poor aqueous solubility is a significant issue in the current pharmaceutical industry with approximately 90% of new chemical entities in the development pipeline characterised as poorly watersoluble.
Amongst various means to address the solubility issue, the amorphous solid…
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A novel amorphous solid dispersion based on drug–polymer complexation
Rafoxanide (RAF) is a poorly water-soluble drug that forms a complex with povidone K25 (PVP) in a cosolvent system containing acetone and an alkaline aqueous medium. This study aims to investigate the impact of RAF-PVP complexation on in vitro and in vivo release of RAF. We prepared two RAF…
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Fused Deposition Modeling (FDM), the new asset for the production of tailored medicines
Over the last few years, conventional medicine has been increasingly moving towards precision medicine. Today, the production of oral pharmaceutical forms tailored to patients is not achievable by traditional industrial means. A promising solution to customize oral drug delivery has been found in…
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A Novel Method for Preparing Stabilized Amorphous Solid Dispersion Drug Formulations Using Acoustic…
A diverse set of drug and polymer combinations have been effectively evaluated utilizing a newly developed method called acoustic fusion to form amorphous solid dispersions (ASD) on the mg-scale, indicating that this approach is a general procedure that can be applied for ASD drug formulations.…
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Liquisolid tablets – A rationale for formulation and process design
A significant proportion of new API’s in development are poorly soluble and require alternative formulation approaches to achieve adequate oral bioavailability. One option is to develop lipid-based formulations. Lipid formulations are typically liquids but can be converted into solid dosage forms…
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