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Solubility Enhancement
Nanosuspension with improved saturated solubility and dissolution rate of cilostazol and effect of…
The aim of the study was to formulate cilostazol containing nanosuspension by top-down wet milling method in order to increase the in vitro solubility and dissolution rate of this substance. The investigation of formulation parameters (emulsifier type, concentration, and combination of…
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Enhancement of solubility and dissolution rate of fenofibrate using β-Cyclodextrin
The aim of the present research work, fenofibrate a BCS class II antihyperlipidemic drug belongs to fibrate class was formulated as solid dispersions using various hydrophilic carriers to enhance the solubility, dissolution rate, and oral bioavailability.
Methodology: Various techniques such as…
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Formulation Development and Solubility Enhancement of Voriconazole by Solid Dispersion Technique
The objective of the present investigation was to formulation development of solid dispersion of voriconazole using hot-melt, solvent evaporation and combination of these two methods together with Gelucire® 44/14, polaxamer 188 and polyvinyl pyrrolidone (PVP) K30 and the different characteristics…
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Cationic self-nanoemulsifying formulations of tamoxifen with improved biopharmaceutical attributes…
A cationic nanoemulsion of tamoxifen (Tmx) containing a charge inducer was developed for improving biopharmaceutical attributes and anticancer potential of the drug. The lipidic formulation constituted of corn oil, labrasol and transcutol HP and optimized using a mixture design by selecting these…
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Design, Fabrication & Characterization of Graft Co-Polymer Assisted Ocular Insert: A State of…
Targeted delivery of drugs at appropriate concentrations to ocular tissues is required to avoid wastage. Hence, advanced systems that maximize the release of poorly soluble drugs and deliver them at ocular sites must be designed.
Methods: In this study, Soluplus® (polyvinyl caprolactam–polyvinyl…
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Opportunities for Successful Stabilization of Poor Glass-Forming Drugs: A Stability-Based Comparison…
Amorphous formulation technologies to improve oral absorption of poorly soluble active pharmaceutical ingredients (APIs) have become increasingly prevalent. Currently, polymer-based amorphous formulations manufactured by spray drying, hot melt extrusion (HME), or co-precipitation are most common.…
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Fabrication and evaluation of fast disintegrating pellets of cilostazol
The present study was designed to formulate and develop fast disintegrating pellets of poorly soluble model drug (cilostazol) by reducing the proportion of micro-crystalline cellulose with pre-gelatinized starch (PGS), lactose and chitosan. The bioavailability enhancement of a model drug was…
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Developing and scaling up fast-dissolving electrospun formulations based on poly(vinylpyrrolidone)…
Poly(vinyl pyrrolidone) (PVP) electrospun fibers loaded with ketoprofen were fabricated in this work as potential fast dissolving drug delivery systems (DDSs) for oral delivery. By changing the processing parameters and collector geometry it was possible to increase the throughput rate from 1 to 20…
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Enhancement of Curcumin Solubility Using a Novel Solubilizing Polymer Soluplus®
In this study, a novel solubility enhancement excipient (Soluplus®) was investigated to improve the solubility and dissolution rate of Curcumin, a poorly water soluble drug.
Methods
Various methods were utilized for the fabrication of Curcumin-Soluplus® mixtures, including the physical mixture,…
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Improving the dissolution of a water-insoluble orphan drug through a fused deposition modelling…
Lennox-Gastaut Syndrome (LGS) is a rare form of childhood epilepsy. Rufinamide is an orphan drug indicated for the treatment of LGS. Three-Dimensional Printing (3DP) is a process in which solid objects are created based on a digital file by adding materials layer by layer. Fused deposition modelling…
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