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Solubility Enhancement
Impact of drying on dissolution behavior of carvedilol-loaded sustained release solid dispersion:…
The present study aimed to develop carvedilol (CAR)-loaded (25% w/w) sustained release solid dispersion (SRSD), for enhanced dissolution and to explore the applicability of different industrially accessible drying techniques.
Methods
SRSD-CAR containing different ratios of polymers were prepared…
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Enhanced oral bioavailability of Bisdemethoxycurcumin-loaded self-microemulsifying drug delivery…
In this study, we sought to overcome the poor solubility and bioavailability of bismethoxycurcumin (BDMC) by fabricating a BDMC-loaded self micro-emulsifying system (BDMC-SMEDDS). Solubility and compatibility tests, pseudo-ternary phase diagrams (PTPDs) as well as d-optimal concept was applied to…
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Polymeric micelles for the delivery of poorly soluble drugs: From nanoformulation to clinical…
Over the last three decades, polymeric micelles have emerged as a highly promising drug delivery platform for therapeutic compounds. Particularly, poorly soluble small molecules with high potency and significant toxicity were encapsulated in polymeric micelles. Polymeric micelles have shown improved…
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Formulation and Optimization of Fluvastatin Loaded Self-emulsifying Drug Delivery Systems
Abstract-Introduction: The current research is aimed at formulating and evaluating fluvastatin self-nanoemulsifying drug delivery system (SNEDDS).
Materials and Methods: Fluvastatin SNEDDS formulated using sefsol-218 (oil), Cremophor RH40 (surfactant), and propylene glycol…
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Overcoming the dissolution rate, gastrointestinal permeability and oral bioavailability of…
Simvastatin (SIM) and glimepiride (GLM) were co-formulated into nanosuspensions and self-nanoemulsifying drug delivery systems (SNEDDS) to improve their dissolution rate and oral bioavailability. Nanosuspension was prepared by liquid anti-solvent precipitation method, involving supersaturation of a…
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β-cyclodextrin polymer/Soluplus® encapsulated Ebselen ternary complex (EβpolySol) as a potential…
Highlights
• β-cyclodextrin polymer showed 3–4 folds higher saturation solubility of Ebselen.
• β-cyclodextrin polymer was safer on HeLa cells compared to monomeric cyclodextrin.
• EβpolySol film rapidly disintegrated and immediately released EB in vaginal fluid.
• EβpolySol film…
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Comparison between Conventional and Supersaturable Self-nanoemulsion Loaded with Nebivolol
Nebivolol (NBH) is a third-generation β1-blocker with high selectivity and vasodilation activity. Nevertheless, nebivolol exhibits low oral bioavailability, which may adversely affect its efficacy. Recently, supersaturable self-nanoemulsion (Su-SNE) is an advanced SNE approach that can address low…
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Cellulose and its derivatives for application in 3D printing of pharmaceuticals
Background
Three-dimensional printing (3DP) has emerged as an advanced manufacturing technology capable of producing complex yet precise medicines intended for patient-centric drug therapy. However, printable materials currently available for 3DP are far too limited.
Area covered
The current…
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Solid Dispersion Pellets: An Efficient Pharmaceutical Approach to Enrich the Solubility and…
Deferasirox (DFX) is an oral iron-chelating agent and classified into class II of the Biopharmaceutics Classification System. Low bioavailability of the drug due to insufficient solubility in physiological fluids is the main drawback of DFX. The idea of the current study was to explore the potential…
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Cannabidiol aqueous solubility enhancement: Comparison of three amorphous formulations strategies…
Poor aqueous solubility of terpenophenolic compound Cannabidiol (CBD) is a major issue in the widespread use of this promising therapeutic polyphenol. Moreover, choosing the appropriate strategy to overcome this challenge is time-consuming and based on trial–error processes. The amorphous form of…
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