Browsing Category
Solubility Enhancement
Polymer Selection for Hot-Melt Extrusion Coupled to Fused Deposition Modelling in Pharmaceutics
Three-dimensional (3D) printing offers the greatest potential to revolutionize the future of pharmaceutical manufacturing by overcoming challenges of conventional pharmaceutical operations and focusing design and production of dosage forms on the patient’s needs. Of the many technologies…
Read More...
Read More...
Synergistic and antagonistic effects of non-ionic surfactants with bile salt + phospholipid mixed…
The nature of the interaction of bile salt micelles with exogenous surfactants used in formulations and the consequent impact on drug solubilisation is not well understood. It is often assumed that addition of any surfactant will lead to an enhanced solubility of drug, which is often true in water…
Read More...
Read More...
A review on developments and prospects of anti-inflammatory administration in microemulsions
Anti-inflammatory drugs often cause diverse side effects and have high lipophilicity, therefore there is a need to search for new anti-inflammatory agents or new drug delivery systems (NDDS) that improve their characteristics. Thus, microemulsions (ME) appear as a good hydrophilic and hydrophobic…
Read More...
Read More...
Enhancing Oral Bioavailability of Apigenin Using a Bioactive Self-Nanoemulsifying Drug Delivery…
Apigenin (APG) is a very well-known flavonoid for its anti-inflammatory and anticancer properties. The purpose of this study is to improve the solubility and bioavailability of APG using a stable bioactive self-nanoemulsifying drug delivery system (Bio-SNEDDS). APG was incorporated in an oil phase…
Read More...
Read More...
Accelerated Aqueous Solubility and Antibacterial Activity of Cefuroxime Axetil Using…
This investigation was undertaken to enhance the solubility and consequent antibacterial activity of cefuroxime axetil (CA), a β-lactamase-stable broad spectrum second generation cephalosporin through solid dispersion (SD) technique. For this purpose, CA loaded SDs (CSDs) were prepared by solvent…
Read More...
Read More...
Eutectic mixtures as an approach to enhance solubility, dissolution rate and oral bioavailability of…
Eutectic mixtures have been known for a long time in the pharmaceutical field. However, its potential as a system to improve the solubility and dissolution of poorly water-soluble drugs remains little explored. Studies involving the microstructural characterization and the preparation of solid…
Read More...
Read More...
Investigation into the Stability, Crystallization Kinetics, and Heating Rate Dependent…
Poor aqueous solubility is a major challenge for formulation scientists as more than 40% of new chemical entities developed in the pharmaceutical industry are insoluble in water. The high energy amorphous form offers enhanced solubility and eventually bioavailability of BCS class II drugs. Because…
Read More...
Read More...
Role of excipients in amorphous solid dispersions
Solid dispersions – a great way to increase the solubility and bioavailability of your drug
In a solid dispersion the drug is dispersed in a carrier with the system appearing to be in a solid state. Target is an increase in solubility and bioavailability. BASF offers both an comprehensive portfolio…
Read More...
Read More...
Supercritical Antisolvent Process for Pharmaceutical Applications: A Review
The supercritical antisolvent (SAS) technique has been widely employed in the biomedical field, including drug delivery, to obtain drug particles or polymer-based systems of nanometric or micrometric size. The primary purpose of producing SAS particles is to improve the treatment of dierent…
Read More...
Read More...
Impact of nanoparticle size and solid state on dissolution rate by investigating modified drug…
Nanoparticles with reduced crystallinity are normally produced by bottom-up (precipitation) processes; however, the drug loading can be limited. The objective was to generate such nanoparticles using modified drugs coupled with high pressure homogenization (HPH) and investigate the coeffects of…
Read More...
Read More...