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Solubility Enhancement
A brief review on solid lipid nanoparticles: part and parcel of contemporary drug delivery systems
Drug delivery technology has a wide spectrum, which is continuously being upgraded at a stupendous speed. Different fabricated nanoparticles and drugs possessing low solubility and poor pharmacokinetic profiles are the two major substances extensively delivered to target sites. Among the colloidal…
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Semi-Phyto Universal Solubilizer (SPUS) for enhancing solubility and bio availability of Bioactive…
Aqueous Solubility of Bio actives plays a significant role in Drug, Biopharma, Food, Dietary and Cosmetic formulations. Poor solubility is one of the biggest hurdles in developing these formulations as well as desired therapeutic effect. It is well proven that more aqueous soluble means rapid…
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Solubility and oral bioavailability enhancement: Gelucire® 48/16 pellets
Gelucire 48/16 is a non-ionic surfactant recommended for use in Lipid-Based Formulations (LBFs) to increase aqueous solubility and oral bioavailability of poorly soluble active ingredients. It is a PEG 32 ester lipid excipient comprising a mixture of stearic and palmitic acid monoesters and…
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Microwave-Induced In Situ Amorphization: A New Strategy for Tackling the Stability Issue of…
The thermodynamically unstable nature of amorphous drugs has led to a persistent stability issue of amorphous solid dispersions (ASDs). Lately, microwave-induced in situ amorphization has been proposed as a promising solution to this problem, where the originally loaded crystalline drug is in situ…
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Self-emulsifying excipient for solubility and oral bioavailability enhancement: Gelucire® 44/14
Gelucire® 44/14 is a non-ionic water dispersible surfactant recommended for use in lipid-based formulations to increase the aqueous solubility and oral bioavailability of poorly water soluble drugs.
A multi-component excipient
Gelucire® 44/14 is obtained by an alcoholysis reaction between…
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Improved oral bioavailability and target delivery of 6-Shogaol via Vitamin E TPGS-modified…
6-Shogaol is one component of ginger, which has been described to possess various health-promoting effects including anticancer, anti-inflammatory, antioxidant and antiatherogenic. However, poor water solubility has limited the aforementioned health benefits and clinical applications of the drug.…
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Computer-Aided Discovery of New Solubility-Enhancing Drug Delivery System
The poor aqueous solubility of active pharmaceutical ingredients (APIs) places a limit on their therapeutic potential. Cyclodextrins (CDs) have been shown to improve the solubility of APIs, but the magnitude of the improvement depends on the structure of both the CDs and APIs. We have developed…
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The design and development of high drug loading amorphous solid dispersion for hot-melt extrusion…
Amorphous solid dispersion (ASD) is a formulation strategy extensively used to enhance the bioavailability of poorly water soluble drugs. Despite this, they are limited by various factors such as limited drug loading, poor stability, drug-excipient miscibility and the choice of process platforms. In…
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Solving the Insoluble with AFFINISOL™ HPMC
AFFINISOL™ hydroxypropyl methylcellulose (HPMC) is a water-soluble cellulosic polymer that can help optimize solubility enhancement by maintaining stable solid dispersions and inhibiting API crystallization.
More sophisticated drug discovery techniques have led to pipeline compounds that require…
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Studies on spectral characterization and solubility of hydroxypropyl β-cyclodextrin/iloperidone…
The antipsychotic drug Iloperidone (ILO) suffers from drawbacks of low solubility and poor bioavailability. In order to overcome such problems, we proposed to prepare binary and ternary complexes using kneading method and further compared for their ability to improve the solubility of ILO. Based on…
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