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Solubility Enhancement
Degrees of order: A comparison of nanocrystal and amorphous solids for poorly soluble drugs
Poor aqueous solubility is currently a prevalent issue in the development of small molecule pharmaceuticals. Several methods are possible for improving the solubility, dissolution rate and bioavailability of Biopharmaceutics Classification System (BCS) class II and class IV drugs.
Two solid state…
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Excipients for Solubility and Bioavailability Enhancement
Active pharmaceutical ingredients (APIs) exhibiting low aqueous solubility or poor intestinal permeability will be associated with poor or variable drug absorption. Lipid-based drug delivery (LBDD) has emerged as a successful approach to improve drug solubilization in the dosage form and, more…
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Amorphous Solid Dispersions in Early Stage of Formulation Development: Predicting Excipient…
Excipients play an important role in the formulation of dosage forms and can be used to improve the bioavailability of a drug through physical interactions that alter the rate of dissolution of a drug. The objective of this study was to predict the effect of formulation on the dissolution rate of a…
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Application and Functional Characterization of Kollicoat Smartseal 30D as a Solid Dispersion Carrier…
Many new chemical entities that are getting developed are poorly aqueous soluble and have low bioavailability. Out of many methods available for improving solubility, the solid dispersion by melt extrusion (ME) and spray drying (SP) is scalable and industrially applicable methods.
Objective: The…
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Hot melt extruded zein for controlled delivery of diclofenac sodium: Effect of drug loading and…
This study evaluates the potential use of zein as an excipient in hot-melt extrusion for controlled delivery of diclofenac sodium (DS). Mixtures of zein, polyethylene glycol and drug were hot melt extruded and cut into 2 mm extrudates. Extrudates were characterised using differential scanning…
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Hot Melt Coating of Amorphous Carvedilol
The use of amorphous drug delivery systems is an attractive approach to improve the bioavailability of low molecular weight drug candidates that suffer from poor aqueous solubility. However, the pharmaceutical performance of many neat amorphous drugs is compromised by their tendency for…
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Advanced formulations “supersaturating drug delivery systems” – A video by UNGAP
An UNGAP video further focussing on specific intraluminal behavior of advanced formulations such as supersaturating drug delivery systems, nanoparticles, and lipid-based and controlled release formulations.
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Oral administration is the most common drug delivery route. Absorption of a…
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Development and Characterization of Liquisolid Tablets Based on Mesoporous Clays or Silicas for…
The aim of this work was to evaluate the effectiveness of mesoporous clays or silicas to develop fast-dissolving glyburide tablets based on a liquisolid approach. Selected clay (Neusilin®US2) and silica (Aeroperl®300) allowed preparation of innovative drug liquisolid systems containing…
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Exploring the feasibility of biopolymers as potential carriers in the formulation of amorphous solid…
Adequate aqueous solubility of active pharmaceutical ingredients (APIs) is a crucial factor for therapeutic effectiveness. Today, more than fifty percent of the new potential APIs are exhibiting poor aqueous solubility/dissolution rate, leading to low and erratic absorption from the…
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Stimulatory Effects of Soluplus® on Flufenamic Acid β-Cyclodextrin Supramolecular Complex:…
The present study demonstrates the solubility and dissolution of flufenamic acid (FLF)/β-cyclodextrin (β-CD)/Soluplus® supramolecular ternary inclusion complex. The binary and ternary inclusion complexes were prepared using solvent evaporation and the microwave irradiation method. The prepared…
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