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Solubility Enhancement
Enhanced Intestinal Absorption of Insulin by Capryol 90
Labrasol® is a self-emulsifying excipient that contains saturated polyglycolysed C6–C14 glycerides and this additive is known to improve the intestinal absorption of poorly absorbed drugs after oral administration. However, the effects of formulations similar to Labrasol® on the intestinal…
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Impact of Magnesium Stearate Presence and Variability on Drug Apparent Solubility Based on Drug…
Excipients are major components of oral solid dosage forms, and changes in their critical material attributes (excipient variability) and/or amount (excipient variation) in pharmaceutical formulations may present a challenge for product performance. Understanding the biopharmaceutical factors…
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Characterization of ternary amorphous solid dispersion containing hypromellose phthalate and…
Hot melt extrusion is a promising technology for producing amorphous solid dispersions, however, there is a risk of thermal degradation or residual crystallinity formation. This caveat may be addressed by optimizing formulations and manufacturing conditions. The aim of our study was to explore…
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Compression-Induced Phase Transitions of Bicalutamide
The formation of solid dispersions with the amorphous drug dispersed in the polymeric matrix improves the dissolution characteristics of poorly soluble drugs. Although they provide an improved absorption after oral administration, the recrystallization, which can occur upon absorption of moisture or…
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Development and characterization of curcumin-loaded solid self-emulsifying drug delivery system…
Highlights
• Soluplus® could be used as a carrier for the entrapment of SEDDS.
• Spray drying is efficient for the preparation of Solid SEDDS with Soluplus®.
• Solid SEDDS in Soluplus® exhibit comparable flow as Neusilin® based adsorbates.
• CUR-SEDDS dissolves faster when trapped…
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Drug Delivery Strategies for Poorly Water-Soluble Silymarin
Silymarin, a mixture of flavonolignan and flavonoid polyphenolic compounds extractable from milk thistle (Silybum marianum) seeds, is gaining an increasingly widespread clinical consensus as a natural remedy in the treatment of numerous chronic liver diseases such as cirrhosis and hepatocellular…
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Encapsulation of Ferulic Acid in Lipid Nanoparticles as Antioxidant for Skin: Mechanistic…
Ferulic acid, though used in formulations of skin-care and cosmetic products, suffers from the problems of poor stability and low aqueous solubility. Encapsulation into nanoparticle can be a viable route to overcome these inherent problems. In this proof-of-concept, we combine experimental studies…
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Formulation technologies and advances for oral delivery of novel nitroimidazoles and antimicrobial…
Antibiotic resistance has become a global crisis, driving the exploration for novel antibiotics and novel treatment approaches. Among these research efforts two classes of antibiotics, bicyclic nitroimidazoles and antimicrobial peptides, have recently shown promise as novel antimicrobial agents with…
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Comparison of induction methods for supersaturation: Amorphous dissolution versus solvent shift
Simple solvent shift is often used to induce supersaturation and investigate precipitation kinetics in early drug development as a substitute for amorphous dissolution. This study develops and compares a small-scale non-sink amorphous dissolution method to a solvent shift method as induction methods…
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Compaction behavior of isomalt after roll compaction
Isomalt is a polyol derived from sucrose. Advantages of this excipient are its sweet taste, which is supposed to allow taste masking, the low glycemic and insulinemic response (Petzoldt, 1982), and the ability to be compacted directly. With regard to infantile patients, also the lack of…
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