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Solubility Enhancement
Mixed micelles of TPGS and Soluplus® for co-delivery of paclitaxel and fenretinide
Fenretinide (4-HPR), as a semi-synthetic retinoid, has apoptosis-promoting effects as a single agent and chemotherapy synergist in vitro. When a human ovarian cancer cells line (A2780s) was treated with both PTX and 4-HPR, there was a synergistic anti-cancer effect demonstrated with a average…
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Therapeutic effects of celecoxib polymeric systems in rat models of inflammation and…
The incidence of rheumatoid arthritis (RA), an autoimmune inflammatory disease, is rapidly increasing in aging societies. In the current study, celecoxib (CXB) micelles were developed to improve the oral absorption and anti-inflammatory effects of CXB in cell studies and λ-carrageenan rat models,…
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Determining Particle Size of Polymeric Micelles in Thermothickening Aqueous Solutions
Many active pharmaceutical ingredients (APIs) are poorly soluble and cause inadequate drug absorption. Soluplus®, a polyvinyl caprolactam-polyvinyl acetate-polyethylene glycol graft copolymer, is a commercial excipient (BASF Corp) that enhances the solubility and bioavailability of many APIs. The…
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Enhancement of loading and oral bioavailability of curcumin loaded self-microemulsifying lipid…
The therapeutic applications of curcumin, a phenolic compound extracted from Curcuma species, is limited due to poor bioavailability. To enhance the bioavailability, self-microemulsifying drug delivery systems (SMEDDS) with curcumin were prepared. Ethyl oleate, Tween 80, and Transcutol® P with…
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Calcitriol Tablets with Hybrid Lipid based Solid Dispersions with Enhanced Stability and Content…
Calcitriol, as the biologically active form of vitamin D3, is essential for patients with renal osteopathy. The solubilization, stabilization, and content uniformity are key issues in its formulation development. In our previous study, the incomplete release of calcitriol was solved by using the…
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Factors affecting the stability and performance of amorphous solid dispersions of poorly soluble…
Over the last twenty years, the poor solubility profile of pipeline drugs has limited their development as solid oral dosage forms. Formulating these APIs as amorphous solid dispersions is one strategy to overcome their poor aqueous solubility. The major limitation to amorphous solid dispersion…
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Thermodynamic Aspects of the Preparation of Amorphous Solid Dispersions of Naringenin with Enhanced…
Amorphous ternary solid dispersions of poorly water-soluble Naringenin (NRG) in Poloxamer 188 (POX) and Neusilin US2 (NSL) were prepared in a Hot- Melt Extruder (HME) using the principle of Low-Temperature Solubilization. Before HME, the NRG-POX solid-state interaction was investigated using Flory…
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Influence of Carbamazepine Dihydrate on the Preparation of Amorphous Solid Dispersions by Hot Melt…
Amorphous solid dispersions (ASDs) are commonly used in the pharmaceutical industry to improve the dissolution and bioavailability of poorly water-soluble drugs. Hot melt extrusion (HME) has been employed to prepare ASD based products. However, due to the narrow processing window of HME, ASDs are…
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Enhanced dissolution, permeation and oral bioavailability of aripiprazole mixed micelles
Aripiprazole (ARP) is an antipsychotic drug approved for the treatment of schizophrenia. It is poorly water-soluble and undergoes extensive hepatic metabolism and P-gp efflux, which lead to poor bioavailability and increased dose-related side effects. This study focuses on the preparation of mixed…
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Influence of Formulation Parameters on Redispersibility of Naproxen Nanoparticles from Granules…
The particle size reduction of active pharmaceutical ingredients is an efficient method to overcome challenges associated with a poor aqueous solubility. With respect to stability and patient’s convenience, the corresponding nanosuspensions are often further processed to solid dosage forms.
In…
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