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Solubility Enhancement
Improved Dissolution and Pharmacokinetics of Abiraterone through KinetiSol® Enabled Amorphous Solid…
Abiraterone is a poorly water-soluble drug. It has a high melting point and limited solubility in organic solvents, making it difficult to formulate as an amorphous solid dispersion (ASD) with conventional technologies. KinetiSol® is a high-energy, fusion-based, solvent-free technology that can…
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The manufacture of fixed dose combination products using advanced pharmaceutical techniques for the…
Thesis by Jeremiah Kelleher, School of Pharmacy and Pharmaceutical Sciences, Trinity College Dublin, The University of Dublin
The thesis has focused on the use of continuous manufacturing techniques to produce fixed dose combination (FDC) products for the treatment of type II diabetes mellitus…
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Multicomponent solid dispersion: A new generation of solid dispersion produced by spray-drying
The term “multicomponent solid dispersion” is widely used in recent literature to describe solid formulations consisting of a special excipient's mixture and active molecules finely dispersed. However, this term has not yet been defined. In this review, we aimed to improve the definition of…
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Preclinical evaluation of new formulation concepts for abiraterone acetate bioavailability…
Abiraterone acetate is a potent drug used for the treatment of metastatic castration resistant prostate cancer. However, currently marketed product containing crystalline abiraterone acetate exhibits strong positive food effect which results in strict dosing regimen.
In the present work, a…
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New Delivery Method Could Make Niclosamide an Effective Antiviral to Treat COVID-19
Repurposing drugs such as the FDA-approved niclosamide is a highly efficient way to leverage drugs with known safety profiles to fight the coronavirus outbreak. College of Pharmacy researchers at The University of Texas at Austin are now using new drug delivery formulation technologies to increase…
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Novel interpenetrating polymeric network based microbeads for delivery of poorly water soluble drug
A well-designed drug delivery platform improves the pharmacological properties of therapeutics. Here, we report a biodegradable interpenetrating polymer network (IPN) microbeads delivery technology developed by crosslinking a polymer blend of poly(vinyl alcohol), xanthan gum, and sodium alginate to…
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Mechanochemical activation with cyclodextrins followed by compaction as an effective approach to…
Rutin is one of the most important flavonoids with poor bioavailability. This work aimed at addressing the issue of poor biopharmaceutical performance of rutin by applying a combination of complexation with secondary processing into tablets. Mechanical activation was the most suitable method of…
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New Delivery Method Could Make Niclosamide an Effective Antiviral to Treat COVID-19
Repurposing drugs such as the FDA-approved niclosamide is a highly efficient way to leverage drugs with known safety profiles to fight the coronavirus outbreak. College of Pharmacy researchers at The University of Texas at Austin are now using new drug delivery formulation technologies to increase…
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Dosage form designs for the controlled drug release of solid dispersions
Although solid dispersions have been reported as an efficient drug delivery system, the design of specific dosage forms for pharmaceutical therapy is necessary to improve the solubility and bioavailability of poorly water-soluble drugs. Solid dispersions can be incorporated in general solid dosage…
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Supersaturated-Silica Lipid Hybrids Improve in Vitro Solubilization of Abiraterone Acetate
Purpose
Abiraterone acetate (AbA) is a poorly water-soluble drug with an oral bioavailability of <10% and a significant pharmaceutical food effect. We aimed to develop a more efficient oral solid-state lipid-based formulation for AbA using a supersaturated silica-lipid hybrid (super-SLH)…
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