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Solubility Enhancement
Screening of stabilizing agents to optimize flurbiprofen nanosuspensions using experimental design
Although flurbiprofen (FB), as one of non-steroidal anti-inflammatory drugs, has various pharmacological applications, it shows low dermal bioavailability due to its low water solubility. To overcome this solubility problem, FB nanosuspensions were developed and the effects of stabilizers were…
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Ellagic Acid Containing Nanostructured Lipid Carriers for Topical Application: A Preliminary Study
Ellagic acid (EA) is a potent antioxidant substance of natural origin characterized by poor biopharmaceutical properties and low solubility in water that limit its use. The aim of the present study was to develop lipid-based nanoparticle formulations able to encapsulate EA for dermal delivery. The…
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Zein nanoparticles as low-cost, safe, and effective carriers to improve the oral bioavailability of…
The clinical translation of the multiple pharmacological effects of resveratrol (RSV) found in preclinical studies has been impaired by its poor bioavailability, due to poor solubility and rapid metabolism and elimination. The inclusion of this molecule in medicines or functional food products will…
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Formulation and In-Vitro Characterization of Solidified Nebivolol Self-Nanoemulsion using Liquisolid…
Recently, supersaturable self-nanoemulsion (Su-SNE) is an advanced approach that can address low oral bioavailability issues. The antihypertensive drug, nebivolol (NBH), has low bioavailability, about 12%, due to its poor solubility and extensive pre-systematic metabolism. This work aimed to convert…
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Rifampicin nanocrystals: Towards an innovative approach to treat tuberculosis
Tuberculosis (TB) is one of the top ten causes of death worldwide and a leading cause of death in HIV patients. Rifampicin (Rif), a low water-soluble drug, is a critical first-line treatment and the most effective drug substance for therapy of drug-susceptible TB. However, Rif has high…
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Fast dissolving nanofibrous matrices prepared by electrospinning of polyaspartamides
Owing to their versatile chemistry, polyaspartamides have recently attracted increased interest in various biomedical uses such as drug delivery systems and scaffolding materials. Their solubility in organic solvents and in water at different values of pH can be fine-tuned by the chemical…
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Effect of the third component on the aging and crystallization of cinnarizine-soluplus® binary solid…
Multiple carriers may be used to prepare solid dispersions (SDs) for different purposes. The aim of this work is to investigate the effect of the third component on the physical stability and physical aging behavior of cinnarizine-soluplus SDs. HPMC, PVP, sorbitol and citric acid were used as the…
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Fluidized and Spouted Bed for the preparation of directly processable amorphous solid dispersions
One of the major challenges for modern formulation development is the increasing number of poorly water-soluble drugs. A common formulation approach to improve the solubility of those poorly soluble active ingredients is to formulate them as amorphous solid dispersions (ASDs) with a suitable polymer…
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Diblock Terpolymers Are Tunable and pH Responsive Vehicles To Increase Hydrophobic Drug Solubility…
28. September 2017
Synthetic polymers offer tunable platforms to create new oral drug delivery vehicles (excipients) to increase solubility, supersaturation maintenance, and bioavailability of poorly aqueous soluble pharmaceutical candidates. Five well-defined diblock terpolymers…
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3rd Technical Seminar on Solubility Enhancement
18. May 2017
13th – 14th June 2017
University of Bradford
Centre for Pharmaceutical Engineering Science
Online Registration
Program & Registration
Seminar 2017-june A4.pdf
Adobe Acrobat Document 2.1 MB
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