Solubility Enhancement

Abstract In the field of pharmaceutical research and development, Fused Deposition Modelling (FDM) 3D printing (3DP) has aroused growing interest within the last ten years. The use of thermoplastic polymers, combined with the melting process of the raw materials, offers the possibility of…
Read More...

Low aqueous solubility of drug candidates is an ongoing challenge and pharmaceutical manufacturers pay close attention to amorphization (AMORP) technology to improve the solubility of drugs that dissolve poorly. Amorphous drug typically exhibits much higher apparent solubility than their crystalline…
Read More...

Candesartan cilexetil (CAN) is administered for treating hypertension and heart failure. CAN suffers poor oral bioavailability, owing to limited aqueous solubility, and first-pass metabolism. Solusomes (novel Soluplus® enriched nano-vesicular carriers) combine the merits of Soluplus®, and the…
Read More...

Abstract Exposing the hydrated-soft-starch matrix of intact grain or reconstituted flour dough to a high-temperature-short-time (HTST) leads to rapid vapor generation that facilitates high-pressure build-up in its elastic matrix linked to large deformation and expansion. The expanded starch matrix…
Read More...

This article is part of the issue: PROCEEDINGS OF THE INTERNATIONAL CONFERENCE OF THE CHINESE RHEUMATOLOGISTS (ICCR) 25–26 November 2023 Abstract Background Ketoprofen (KPN) is commonly prescribed drug to alleviate pain related with rheumatoid arthritis (RA).…
Read More...

Abstract This review aims to provide a thorough examination of the benefits, challenges, and advancements in utilizing lipids for more effective drug delivery, ultimately contributing to the development of innovative approaches in pharmaceutical science. Lipophilic drugs, characterized by low…
Read More...

The research work aimed to develop a robust sustained release biocompatible brinzolamide (BRZ)-loaded ocular inserts (MeltSerts) using hot-melt extrusion technology with enhanced solubility for glaucoma management. A 32 rotatable central composite design was employed for the optimization of the…
Read More...

Abstract Purpose The primary aim of this study is to introduce Therapeutic Deep Eutectic Systems (THEDES) as a novel, green, and biocompatible solvent system for the delivery of diclofenac diethylamine (DDEA), a non-steroidal anti-inflammatory drug. The research question focuses on whether THEDES…
Read More...

We invite you to our next webinar: "Rational Selection of Cyclodextrins for the Solubilization of Poorly Soluble Oral Drugs" Poorly soluble drugs for oral administration present unique formulation challenges, particularly during early development. Formulation in a complex with…
Read More...

Overview of the article The Importance of API Solubility for Solid and Liquid Dosage Forms The Solubilization Process The Biopharmaceutics Classification System of APIs The Developability Classification System The Central Role of Solubility and Permeability for API Absorption…
Read More...