Synergising excipients to boost skin delivery: A case study with lidocaine hydrochloride
In this study lidocaine hydrochloride (LID HCl), a local anesthetic agent, was used to evaluate the solubilizing performance of each CPE. An in-vitro permeation study was conducted using vertical diffusion cells (Franz cells, Strat-M membrane) to compare the diffusion capacity of CPE alone or in mixtures, with the same thermodynamic activity.
This study aimed to identify synergic mixtures of CPEs that enable the solubilization and diffusion/permeation of LID HCl through the membrane.
Have a look at the poster (Click for enlargement):
