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Solvent
Acetaminophen Synthesis and Encapsulation using Safe Mixed-Solvents and Solution Enhanced Dispersion…
Acetaminophen (ACMP) was synthesized in mixed-solvents (H2O-acetone, H2O-dimethyl sulfoxide, H2O-isopropyl alcohol) for purposes of eliminating hazardous dipolar aprotic solvents. The H2O-acetone solvent-pair gave synthesized ACMP yields of 79.2%. Synthesized ACMP samples were encapsulated using…
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Novel Gels: An Emerging Approach for Delivering of Therapeutic Molecules and Recent Trends
Gels are semisolid, homogeneous systems with continuous or discrete therapeutic molecules in a suitable lipophilic or hydrophilic three-dimensional network base. Innovative gel systems possess multipurpose applications in cosmetics, food, pharmaceuticals, biotechnology, and so forth. Formulating a…
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Semi-solid extrusion 3D printing of tailored ChewTs for veterinary use – A focus on…
Currently, there are a few or none marketed gabapentin veterinary products, leading to treatment with compounded dosage forms or off-label use of human-marketed products. With the said approaches, there are significant risks of preparation errors, rendering these practices suboptimal. A new…
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Enhancement of Tablet Coating using an Innovative Functional Excipient
During formulation of solid dosage forms, film coating is used to improve the appearance and stability of tablets, make them easier to swallow, mask the taste, modify or sustain release, protect the drug from the harsh gastric environment, protect from moisture and/or oxidation and, as a result, to…
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Solid Dispersion of Artemether in Fast Disintegrating Tablet to Enhance Dissolution Rate and Oral…
Objectives: Artemether (ART), an antimalarial drug, have poor solubility and low bioavailability. Therefore, solid dispersion of the drug was formulated using Soluplus (SOL) and was incorporated in the fast disintegrating tablet.
Materials and Methods: The solid dispersion (SD) was prepared using…
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Concept of Orodispersible or Mucoadhesive “Tandem Films” and Their Pharmaceutical Realization
Orodispersible or mucoadhesive films as a patient-oriented dosage form for low-dosed drugs are usually produced using solvent casting. This paper presents a modification of the solvent casting technique that aimed to divide oral films into two or more compartments.
The proposed objectives and…
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Solid Dispersion of Lumefantrine Using Soluplus® by Solvent Evaporation Method: Formulation,…
Objectives: Lumefantrine (LUM) is an antimalarial drug having poor aqueous solubility. The objective was to formulate the solid dispersion of LUM and improve the solubility and dissolution rate.
Materials and Methods: Solvent evaporation technique was used to prepare solid dispersions (SDs) with…
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Technology of Processing Plant Extracts Using an Aluminometasilicate Porous Carrier into a Solid…
A method of preparing tablets called liquisolid technique is currently emerging. In these formulations, an important role is played by porous carriers, which are the basic building blocks of liquisolid systems (LSSs). The most common are microcrystalline cellulose (MCC), magnesium…
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Best practices in current models mimicking drug permeability in the gastrointestinal tract –…
The absorption of orally administered drug products is a complex, dynamic process, dependent on a range of biopharmaceutical properties; notably the aqueous solubility of a molecule, stability within the gastrointestinal tract (GIT) and permeability. From a regulatory perspective, the concept of…
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Development of Sustained Release Eudragit Based Matrix Tablet of Fluvastatin Sodium Microspheres
The purpose of this research is to investigate the suitability of acquiring improved dissolution profile and sustained release of Fluvastatin sodium to reduce dosage frequency via a novel combination of freeze dried microspheres and Eudragit polymers-based matrix tablet technologies. Fluvastatin…
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