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Solvent
Quality by Design applied to the development of soft gelatin capsules
The pandemic we are experiencing made us realize the impact and need for medication in patients' lives. These, in turn, are substances that contain drugs in their composition, the so-called active principles responsible for alleviating various symptoms. In this sense, the article will address some…
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Cyclodextrin as Functional Carrier in Development of Mucoadhesive Tablets Containing Polygoni…
Polygoni cuspidati root is a resveratrol-rich source with anti-inflammatory, angiogenic and neuroprotective effects. The raw material was standardized for the content of resveratrol, for which there is a special justification for administration within the oral mucosa. To improve the solubility of…
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In situ solvent removal-based Eudragit®L/dimethyl sulfoxide forming gel for periodontal pocket drug…
Periodontitis is a chronic inflammatory disease of gum resulting from Porphyromonas gingivalis infectious at periodontal pockets. In situ forming gel (ISG) effectively delivers the antimicrobial agents to this targeted site. This study was to develop the dimethyl sulfoxide (DMSO) removal-based ISGs…
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In Vitro Evaluation of a Solid Supersaturated Self Nanoemulsifying Drug Delivery System…
Aprepitant (APR) belongs to Class II of the Biopharmaceutical Classification System (BCS) because of its low aqueous solubility. The objective of the current work is to develop self-nanoemulsifying drug delivery systems (SNEDDS) of APR to enhance its aqueous solubility. Preformulation studies…
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Solubility: Definition and explanation by Pharma Drama
It's probably the most important physicochemical property of a drug, but what actually is solubility? Pharma Drama is here to give you the solution! In this Snug, we look at the basics of solubility - how it's defined and how it's measured.
Watch the video here:…
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Development of Glimepiride Loaded Sustained Release Microparticles Using Tubular Microreactor
Background: Glimepiride is a third-generation, oral anti-diabetic sulfonylurea drug, generally recommended for the treatment of type–II diabetes. A biocompatible polymer, Eudragit RS 100 is widely used for the preparation of targeted and time-controlled release of drugs. Glimepiride is encapsulated…
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Enhanced oral bioavailability of rutin by a self-emulsifying drug delivery system of an extract of…
The aim of this study was to develop and optimize a self-emulsifying drug delivery system (SEDDS) containing an extract of calyces from Physalis peruviana with high mucus permeating properties to increase the bioavailability and the hypoglycemic activity of the active metabolites of the extract. The…
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Solvent Emulsification Evaporation and Solvent Emulsification Diffusion Techniques for Nanoparticles
Nowadays, there has been an increased demand of nanoparticulate-based drug delivery as nanoparticles (NPs) generally give more advantages over the conventional drug carriers for targeting in various parameters like more drug encapsulation, more stability and site specificity, sustained release…
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Pharmaceutical amorphous solid dispersion: A review of manufacturing strategies
Amorphous solid dispersions (ASDs) are popular for enhancing the solubility and bioavailability of poorly water-soluble drugs. Various approaches have been employed to produce ASDs and novel techniques are emerging. This review provides an updated overview of manufacturing techniques for preparing…
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GE11 Modified PLGA/TPGS Nanoparticles Targeting Delivery of Salinomycin to Breast Cancer Cells
Abstract:
Salinomycin (Sal) is a potent inhibitor with effective anti-breast cancer properties in clinical therapy. The occurrence of various side effect of Sal greatly limits its application. The epidermal growth factor receptor (EGFR) family is a family of receptors highly expressed in most…
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