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Solvent
Effects of Solvents, Emulsions, Cosolvents, and Complexions on Ex Vivo Mouse Myometrial…
A great need exists to develop tocolytic and uterotonic drugs that combat poor, labor-related maternal and fetal outcomes. A widely utilized method to assess novel compounds for their tocolytic and uterotonic efficacy is the isometric organ bath contractility assay. Unfortunately, water-insoluble…
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Oral delivery of peptide therapeutics in infants: Challenges and opportunities
Abstract: The vast majority of drugs are not designed or developed for pediatric and infant populations. Peptide drugs, which have become increasingly relevant in the past several decades, are no exception. Unfortunately, nearly all of the 60+ approved peptide drugs are formulated for…
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An Investigation of the Influence of PEG 400 and PEG-6-Caprylic/Capric Glycerides on Dermal Delivery…
Polyethylene glycols (PEGs) and PEG derivatives are used in a range of cosmetic and pharmaceutical products. However, few studies have investigated the influence of PEGs and their related derivatives on skin permeation, especially when combined with other solvents. Previously, we reported…
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Pharmaceutical Material Engineering: Evaluation of Carvedilol Polymorphs II and III Surface by…
Solid forms can influence the dissolution, stability, and processability of active pharmaceutical ingredients. However, besides the internal arrangement, crystal habit studies are important, since the exposure of different crystal faces (surfaces) can influence pharmaceutical properties. In this…
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Transcutol® P Containing SLNs for Improving 8-Methoxypsoralen Skin Delivery
Topical psoralens plus ultraviolet A radiation (PUVA) therapy consists in the topical application of 8-methoxypsoralen (8-MOP) followed by the skin irradiation with ultraviolet A radiation. The employment of classical 8-MOP vehicles in topical PUVA therapy is associated with poor skin deposition and…
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What is the Role of Over 100 Excipients in Over the Counter (OTC) Cough Medicines?
by Eccles, R. What is the Role of Over 100 Excipients in Over the Counter (OTC) Cough Medicines?. Lung (2020). https://doi.org/10.1007/s00408-020-00390-x
Most medicines are white bitter powders that are formulated as tablets and capsules but cough medicines are an exception where the taste and…
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Preparation, optimization and preliminary pharmacokinetic study of curcumin encapsulated turmeric…
The present investigation aimed to develop curcumin loaded turmeric oil microemulsion for brain targeting. An effort has been made to investigate the role of functional components in developing brain targeted formulation which could enhance the bioavailability and uptake of drug in the brain upon…
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Lyophilization of Small-Molecule Injectables: An Industry Perspective on Formulation Development,…
Lyophilization is a pivotal manufacturing process to obtain a stable drug product that is unstable as a ready-to-use formulation. Some formulations may require the addition of drug-specific excipients such as stabilizers, buffers, and bulking agents to support the cake appearance and ensure…
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Hybridized nanoamorphous micellar dispersion using a QbD–DM3 linked rational product design strategy…
A QbD-DM3 linked rational product design strategy was adopted to create a hybridized ritonavir (RTV, BCS Class IV) nanoamorphous micellar dispersion (RTV-NAD). A DM3 research strategy was employed in conjunction with the quality-by-design spaces, and quality target product profile to link the…
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Studying effect of glyceryl palmitostearate amount, manufacturing method and stability on…
Rifaximin (RFX) exhibit polymorphism and commercial formulation contains the α form. The polymorphic transformation of the RFX in the drug product have significant effect on the clinical outcome. The focus of present work was to understand effect of formulation component and manufacturing method,…
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