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Solvent
Fabrication of Orally Fast Disintegrating Wafer Tablets Containing Cannabis Extract Using Freeze…
Abstract
Introduction: The development of a novel dosage form for cannabis extract is necessary to improve drug delivery
and to also enhance patient convenience.
Methods: Orally fast disintegrating wafer tablets containing cannabis extract, which were prepared using the
freeze drying…
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Mirtazapine loaded polymeric micelles for rapid release tablet: A novel formulation – In vitro…
Major depression is a prevalent disorder characterized by sadness, lack of interest or pleasure, interrupted sleep or food, and impaired concentration. Mirtazapine (MTZ), a tetracyclic antidepressant drug, is commonly used to treat moderate to severe depression. MTZ is classified as a BCS class II…
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Self-microemulsifying system of an ethanolic extract of Heliopsis longipes root for enhanced…
Abstract
Self-microemulsifying or self-nanoemulsifying drug delivery systems (SMEDDS/SNEDDS) are well known to improve the dissolution and increase the oral bioavailability of hydrophobic drugs, including herbal extracts. Organic extracts of Heliopsis longipes root and affinin, its main component,…
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A Comprehensive Review of Disintegrants: Backbone of disintegration
Abstract
Strong attractive bonding forces works among the particles of solid dosage forms such as mechanical, solid and intermolecular and bioavailability of solid dosage form is preferentially dependent on in vivo disintegration then dissolution. This review is focused for disintegrating agents,…
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In Vitro and Biological Evaluation of Oral Fast-Disintegrating Films Containing Ranitidine HCl and…
Flurbiprofen (FBP), a nonsteroidal anti-inflammatory drug (NSAID), is commonly used to treat the pain of rheumatoid arthritis, but in prolonged use it causes gastric irritation and ulcer. To avoid these adverse events of NSAIDs, the simultaneous administration of H2 receptor antagonists such as…
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Solvent-free method for masking the bitter taste of azithromycin dihydrate using supercritical fluid…
Abstract
Introduction and purpose
The unpleasant extremely bitter taste of the orally administered broad-spectrum antibiotic azithromycin decreases patient compliance, especially in pediatrics. This issue can be overcome by decreasing drug interaction with the tasting buds using insoluble…
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Anti-Inflammatory Drug Repurposing for Intranasal Delivery: Ketoprofen Nanoemulgel Development for…
The anti-inflammatory drug ketoprofen has shown promising results in the field of drug repurposing for the treatment of brain cancer, but currently developed formulations are for invasive administration (intravenous) and have very limited drug strength. Hence, the purpose of this work was to develop…
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Enhanced in vivo absorption and biodistribution of curcumin loaded into emulsions with high…
The health benefits of curcumin have been demonstrated by clinical studies, but its low bioavailability compromises its functionality. In this regard, emulsions have proven to be effective encapsulation systems for curcumin. Nevertheless, emulsions with a high oil content (50%) may offer some…
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Nanosuspensions as carriers of active ingredients: Chemical composition, development methods, and…
Nanosuspensions (NSps) are colloidal dispersions of particles that have the potential to solve the delivery problems of active ingredients associated with their low solubility in water or instability due to environmental factors. It is essential to consider their chemical composition and preparation…
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Combination of time-dependent polymer and inulin as a coating for sustained delivery of budesonide…
Crohn's disease and ulcerative colitis, both forms of inflammatory bowel disease (IBD), are prevalent conditions. Budesonide, a medication widely recommended as a first-line treatment for Crohn's disease, necessitates the development of formulations capable of delivering the drug to the intestinal…
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