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Solvent
Development and Characterization of Cyclodextrin-Based Nanogels as a New Ibuprofen Cutaneous…
Nanogels combine the properties of hydrogels and nanocarrier systems, resulting in very effective drug delivery systems, including for cutaneous applications. Cyclodextrins (CDs) have been utilised to enhance the nanogels’ loading ability towards poorly soluble drugs and promote/sustain drug…
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The Formula For Stability – High-quality excipients for your plasma-derived products
Quality for your formulation, stability for your products.
To solve the challenge of stability requirements in plasma applications, we offer a wide range of high-quality pharmaceutical excipients that allow you to formulate and manufacture stable plasma products.
These include pH…
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Neither too little nor too much: finding the ideal proportion of excipients using confocal Raman and…
The applications of Raman imaging in pharmaceutical field are ever-increasing due its ability to obtain spatial and spectral information simultaneously, once it allows determine the chemical distribution of compounds. In this sense, it is used to study homogeneity, of paramount importance during the…
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How to Improve Solubility and Dissolution of Irbesartan by Fabricating Ternary Solid Dispersions:…
The purpose of this study is to improve the solubility and dissolution of a poorly soluble drug, Irbesartan, using solid dispersion techniques. For that purpose, different polymers such as Soluplus®, Kollidon®VA 64, Kolliphor®P 407, and Polyinylpyrrolidone (PVP-K30) were used as carriers at…
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Antipsychotics-Loaded Nanometric Emulsions for Brain Delivery
Antipsychotic drugs have numerous disabling side effects, and many are lipophilic, making them hard to formulate at high strength. Incorporating them into nanometric emulsions can increase their solubility, protect them from degradation, and increase their brain delivery, being a promising strategy…
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Drug delivery to the brain: In situ gelling formulation enhances carbamazepine diffusion through…
The objective of this work was to optimize a thermosensitive in situ gelling formulation to improve intranasal and nose-to-brain delivery of the antiepileptic drug carbamazepine (CBZ). A preliminary procedure of vehicles obtained just mixing different fractions of poloxamer 407 (P407) and poloxamer…
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Optimization of Lipid Nanoparticles by Response Surface Methodology to Improve the Ocular Delivery…
Diosmin is a flavonoid with a great variety of biological activities including antioxidant and anti-inflammatory ones. Its cytoprotective effect in retinal pigment epithelium cells under high glucose conditions makes it a potential support in the treatment of diabetic retinopathy. Despite its…
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Poloxamer: a simple and powerful solution for accelerating dissolution
Oral administration is the most commonly employed route for drug delivery. It is cost-effective and convenient for the patient, leading to high patient compliance. In order for the API to exert a physiological effect it must pass from the gastrointestinal (GI) tract and into the systemic…
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Design of Liposomal Lidocaine/Cannabidiol Fixed Combinations for Local Neuropathic Pain Treatment
The administration of drug fixed combinations by nanocarriers is a new attractive approach since it can allow improvements in both the skin penetration of cargo compounds and their synergistic effects. The cutaneous administration of lidocaine (LD) and cannabidiol (CBD) combination can be useful for…
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Efficient Delivery of DNA Using Lipid Nanoparticles
DNA vaccination has been extensively studied as a promising strategy for tumor treatment. Despite the efforts, the therapeutic efficacy of DNA vaccines has been limited by their intrinsic poor cellular internalization. Electroporation, which is based on the application of a controlled electric field…
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