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Solvent
In Vitro Release, Mucosal Permeation and Deposition of Cannabidiol from Liquisolid Systems: The…
This work investigated the influence of liquid vehicles on the release, mucosal permeation and deposition of cannabidiol (CBD) from liquisolid systems. Various vehicles, including EtOH, nonvolatile low- and semi-polar solvents, and liquid surfactants, were investigated. The CBD solution was…
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Enhancement of the Bioavailability and Anti-Inflammatory Activity of Glycyrrhetinic Acid via Novel…
Glycyrrhetinic acid (GA) is an anti-inflammatory drug with potential for development. However, the poor solubility of GA in water leads to extremely low bioavailability, which limits its clinical applications. Solid dispersions have become some of the most effective strategies for improving the…
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Excipients for veterinary application – IOI Oleo
See an overview of the IOI Oleo specialties for Veterinary Applications.
They are used for companion as well as for farm animals in following uses:
• Injectables - SC and IM
• Infusions - IV
• Oral (e.g. paste, drench)
• Pour-on / Spot-on formulations
• Tick and flea collars
…
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Witepsol – Hard fats for suppositories and ovules by IOI Oleochemical
1| HARD FACTS ABOUT OUR HARD FATS
The brand name WITEPSOL® is synonym for hard fats mainly used in suppositories and ovules.
Development and production of WITEPSOL® started back in the 1950s at the former Chemische Werke Witten, now known as IOI Oleo GmbH.
Manufacturing takes place in a fully…
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Targeted colonic release formulations of mesalazine – A clinical pharmaco-scintigraphic…
Colonic targeting of orally applied therapeutic drugs remains a challenge. Tablet coatings relying on gastrointestinal pH and colonic bacterial enzymes as triggers in association with an inner alkaline layer are expected to improve targeting efficiency. Mesalazine release from three differently…
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Formulation and optimization of Paliperidone palmitate biodegradable injectable microspheres using…
The objective of study was to formulate and optimize poly lactic-co-glycolic acid based long-acting injectable microspheres of Paliperidone palmitate (PP) using Box- Behnken design for treatment of schizophrenia. The oral bioavailability of PP is 28%, it necessitates the formulation of PP in…
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Production, physicochemical investigations, antioxidant effect, and cellular uptake in Caco-2 cells…
The purpose of this study was to develop astaxanthin (AST)-loaded self-microemulsifying drug delivery system (SMEDDS) tablets and evaluate their physicochemical and biological properties. The optimized liquid (L)-AST SMEDDS formulation was composed of rice bran oil (33.67%), Kolliphor® RH 40…
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In vivo and in vitro per se effect evaluation of Polycaprolactone and Eudragit® RS100-based…
Biodegradable polymeric nanocapsules (NC) present incredible characteristics as drug nanocarriers that optimize drug targeting. However, However, a more detailed isolated effect of polymer-based nanoparticles as drug carriers is required. This work aimed to evaluate the per se effect of blank-NC…
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An Insight into Preparatory Methods and Characterization of Orodispersible Film—A Review
Over the past few decades, researchers and companies have been trying to develop novel drug delivery systems to ensure safety, efficacy, compliance, and patient acceptability. Nowadays drug discovery and development are expensive, complex, and time-consuming processes, but trends are moving toward…
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Lipid based intramuscular long-acting injectables: current state of the art
Long acting injectables (LAI) have received increased research and commercial interest due to their potential for improving treatment effectiveness and adherence for antipsychotic, antiviral and addiction treatments. A range of materials have been used to formulate LAI products, including lipids and…
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