Spray drying

Introduction Controlled release dosage forms deliver an effective dose of the active pharmaceutical ingredient over a prolonged duration, which is particularly advantageous to maintain a constant plasma drug concentration within the therapeutic window. This effectively overcomes the negative…
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Introduction Spray drying is a common process to isolate solid products from emulsions, dispersions or solutions. A wide range of products are produced by spray drying: Food products (e.g., tomato powder, soup mixes, flavors, non-dairy creamer, egg powder) Milk and Dairy products…
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Amorphous solid dispersions feature prominently in the approach to mitigate low bioavailability of poorly water-soluble small molecules, particularly in the early development space focusing on toxicity evaluations and clinical studies in normal healthy volunteers, where high exposures are needed to…
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Spray drying is one of the most frequently used solvent-based processes for manufacturing amorphous solid dispersions (ASDs). However, the resulting fine powders usually require further downstream processing when intended for solid oral dosage forms. In this study, we compare properties and…
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Since famotidine (FA) is prescribed for gastrointestinal diseases orodispersible tablets could contribute to patients’ compliance. Its bitter taste and poor compressibility pose formulation challenges which were addressed in this study. Famotidine/mannitol (FA/MA) binary solution was spray dried…
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Co-processing of APIs, the practice of creating multi-component APIs directly in chemical processing facilities used to make drug substance, is gaining increased attention with a view to streamlining manufacturing, improving supply chain robustness and accessing enhanced product attributes in terms…
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See the 4th Seminar on Amorphous Solid Dispersion. As technology provider in the field of ASD, Shin-Etsu together with the partners Alexanderwerk, Frewitt, PROCEPT and Thermo Fisher Scientific, will share latest insights of ASD development steps ranging from initial screening phase up to downstream…
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Amorphous solid dispersions have gained tremendous attention as a commercially viable solubility enhancement technique for poorly water-soluble drugs. However, poor drug loading associated with poor drug-polymer miscibility is a major challenge in the downstream processing of ASDs. While many…
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Drying means the removal of water (or other solvent) from a sample, but why do we do that and how does it work? In this video, Pharma Drama helps you to Get Drying Sorted! We'll explain why we dry materials, how drying methods work, explain the four stages of convective drying and briefly look at…
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A fine, hygroscopic, and poorly flowable probiotic powder encapsulating Lactobacillus rhamnosus GG (LGG) was granulated using a high-shear granulation process, wherein a small amount of water (4%, w/w) was used for moisture-activation with or without 10% (w/w) resistant maltodextrin (RM). The…
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