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Spray drying
Preparation of Free-Flowing Spray-Dried Amorphous Composites Using Neusilin®
A highly porous additive, Neusilin®, with high adsorption capability is investigated to improve bulk properties, hence processability of spray-dried amorphous solid dispersions (ASDs). Griseofulvin (GF) is applied as a model BCS class 2 drug in ASDs. Two grades of Neusilin®, US2 (coarser) and UFL2…
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Composition-Property Relationships of pH-Responsive Poly[(2-vinylpyridine)-co-(butyl methacrylate)]…
The taste-masking of bitter-tasting active pharmaceutical ingredients is key to ensuring patient compliance when producing oral pharmaceutical formulations. This is generally achieved via the incorporation of pH-responsive, reverse enteric polymers, that prevent the dissolution of the formulation in…
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Introducing the application of F-Melt® for manufacturing oral disintegrating tablets (ODTS) of…
See the fifth issue of Fuji Chemical Industries Technical Newsletter. It presents the application of F-Melt® for manufacturing oral disintegrating tablets (ODTS) of Simvastatin.
ORAL DISINTEGRATING TABLETS OF SIMVASTATIN WITH F-MELT®
F-Melt® is a co-processed spray-dried excipient system…
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The applications of machine learning to predict the forming of chemically stable amorphous solid…
Amorphous solid dispersion (ASD) is one of the most important strategies to improve the solubility and dissolution rate of poorly water-soluble drugs. As a widely used technique to prepare ASDs, hot-melt extrusion (HME) provides various benefits, including a solvent-free process, continuous…
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Microencapsulation by a Spray Drying Approach to Produce Innovative Probiotics-Based Products…
Recently, there has been a growing interest in producing functional foods containing encapsulated probiotic bacteria due to their positive effects on human health. According to their perceived health benefits, probiotics have been incorporated into a range of dairy products, but the current major…
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Transform Your Brick-Dust API into an Effective oral Drug Candidate with Apinovex Polymers
Lubrizol Apinovex™ polymers can be easily incorporated into your drug project via spray drying or other solvent-based processes. This novel excipient has a broad API and solvent compatibility to produce Amorphous Solid Dispersions (ASD) of your brick-dust API.
1. Unlock the Potential Of…
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Engineering the right formulation for enhanced drug delivery
Dry powder inhalers (DPIs) can be used with a wide range of drugs such as small molecules and biologics and offer several advantages for inhaled therapy. Early DPI products were intended to treat asthma and lung chronic inflammatory disease by administering low-dose, high-potency drugs blended with …
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Development of spray-dried N-acetylcysteine dry powder for inhalation
N-acetylcysteine (NAC) has both antioxidant and immunomodulatory activities and has been used as adjuvant therapy in several viral infections. Recently, NAC attracted attention for its possible role in reducing the affinity of the spike protein receptor binding domain to angiotensin-converting…
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Apinovex Polymers Enable Solubility With Ease
Apinovex™ polymers can be easily incorporated into your drug project via spray drying or other solvent-based processes. This novel excipient has a broad API and solvent compatibility to produce Amorphous Solid Dispersions (ASD) of your brick-dust API.
Solubility-enhancing polymers for oral…
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Batch versus continuous blending of binary and ternary pharmaceutical powder mixtures
The material properties of excipients and active pharmaceutical ingredients (API's) are important parameters that affect blend uniformity of pharmaceutical powder formulations. With the current shift from batch to continuous manufacturing in the pharmaceutical industry, blending of excipients and…
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