Browsing Category
Spray drying
Pharmaceutical nanotechnology: from the bench to the market
Background
Nanotechnology is considered a new and rapidly emerging area in the pharmaceutical and medicinal field. Nanoparticles, as drug delivery systems, impart several advantages concerning improved efficacy as well as reduced adverse drug reactions.
Main body
Different types of nanosystems…
Read More...
Read More...
Relative bioavailability enhancement of simvastatin via dry emulsion systems: comparison of spray…
Comprehensive comparisons of similar lipid based drug delivery systems produced by different technologies are scarce. Spray drying and fluid bed layering technologies were compared with respect to the process and product characteristics of otherwise similar simvastatin loaded dry emulsion systems.…
Read More...
Read More...
Impact of Swelling of Spray Dried Dispersions in Dissolution Media on Their Dissolution: An…
Impact of SDD-dissolution medium interactions on the swelling and dissolution of spray dried dispersions (SDDs) was investigated using UV imaging by monitoring SDD swelling in situ, along with correlating of the swelling with the micro-dissolution and intrinsic dissolution of SDDs. SDDs of…
Read More...
Read More...
Pectin microparticles for peptide delivery: optimization of spray drying processing
Spray-dried pectin microparticles can potentially improve the oral bioavailability of peptides by virtue of their mucoadhesion. However, developing such formulations with desirable quality attributes is challenging due to the sensitivity of microparticle critical quality attributes towards changes…
Read More...
Read More...
Spherical Agglomerates of Lactose Reduce Segregation in Powder Blends and Improve Uniformity of…
We report here on improved uniformity of blends of micronised active pharmaceutical ingredients (APIs) using addition of spherical agglomerates of lactose and enhanced blend flow to improve tablet content uniformity with higher API loads. Micromeritic properties and intra-particle porosity (using…
Read More...
Read More...
Engineered-inhaled particles: influence of carbohydrates excipients nature on powder properties and…
Pulmonary drug administration has long been used for local or systemic treatment due to several advantages. Dry powder inhalers emerge as the most promising due to efficiency, ecologic, and drug stability concerns. Coarse lactose-carrier is still the gold standard when inhalation powders are…
Read More...
Read More...
Spray-freeze-dried inhalable composite microparticles containing nanoparticles of combinational…
The multi-drug resistance of Pseudomonas aeruginosa is an overwhelming cause of terminal and persistent lung infections in cystic fibrosis (CF) patients. Antimicrobial synergy has been shown for colistin and ivacaftor, and our study designed a relatively high drug-loading dry powder inhaler …
Read More...
Read More...
Self-nanoemulsifying composition containing curcumin, quercetin, Ganoderma lucidum extract powder…
Liquid self-nanoemulsifying drug delivery system (L-SNEDDS) of curcumin and quercetin were prepared by dissolving them in isotropic mixture of Labrafil M1944CS®, Capmul MCM®, Tween-80® and Transcutol P®. The prepared L-SNEDDS were solidified using Ganoderma lucidum extract, probiotics and…
Read More...
Read More...
Design and Characterization of HY-038 Solid Dispersions via Spray Drying Technology
The aim of this study was to prepare HY-038 solid dispersions (SDs) with single carrier at high drug loading and then forming a tablet to enhance solubility, dissolution, and bioavailability via spray drying technology. At the same time, we hope to develop a more convenient in vitromethod to predict…
Read More...
Read More...
On the Feasibility of Spray-Dried Eudragit-Trehalose Microparticles for Enteric Drug Delivery
Enteric infections have long constituted a silent epidemic responsible for hundreds of thousands of deaths around the world every year. Because of the global rise in antibiotic-resistant bacteria and the slow development of new small-molecule antibiotics, alternatives such as bacteriophage therapy…
Read More...
Read More...