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Spray drying
Pharmaceutical application and development of fixed-dose combination: dosage form review
Background
Fixed dose combination (FDC) products are common in the treatment of various disease such as hypertension, diabetes, HIV and HCV, Pain, Respiratory disease for improving therapeutic efficacy and tolerability. They make it possible to combine more than two drug molecules with optimal…
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Flowing properties of spray-dried powders before and after granulation
Abstract
We study the flowing properties, the density and the packing dynamics of spray-dried powders produced with different nozzels and different airflow rates. At the exception of one powder, the obtained grains are small and have a low flowability due to cohesiveness. Therefore, an…
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Recent and Relevant Methodology in the Advancement of Solid Dispersion
Most of the promising drugs in development channels are poorly water-soluble drugs which limit formulation approaches, clinical application because of their low dissolution and bioavailability. And the major current challenges of the pharmaceutical industry are apropos strategies that improve the…
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Web-Seminar series: Advances In Amorphous Solid Dispersion Technologies: Spray drying
In this series of webinars we will discuss the latest developments in the fields of amorphous solid dispersion (ASD) focusing on Excipient Key Attributes linked to the most popular technologies: Hot Melt Extrusion (HME), Spray Drying and their Downstream Processing.
Wednesday 22 September, 3pm…
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Design of experiment of redispersible spray dried powder of fatty acid-nanostructured lipid carriers…
Fatty acid such as lauric and oleic acid have been used extensively either in cosmeceutical or pharmaceutical products as an emollient or moisturiser. In this study, fatty acids which combine lauric and oleic acids have been formulated into nanostructured lipid carriers (FA-NLCs) system in order to…
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Uniform lactose microspheres with high crystallinity fabricated by micro-fluidic spray drying…
Crystalline lactose microparticles with uniform size and spherical shape are greatly desirable for various applications, but still challenging. Herein, uniform lactose microspheres with high crystallinity were fabricated via spray drying lactose/polyethylene glycol (200 Da) (PEG 200) combined with…
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Encapsulation of Phenolic Compounds from a Grape Cane Pilot-Plant Extract in Hydroxypropyl…
Grape canes, the main byproducts of the viticulture industry, contain high-value bioactive phenolic compounds, whose application is limited by their instability and poorly solubility in water. Encapsulation in cyclodextrins allows these drawbacks to be overcome. In this work, a grape cane…
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Evaluation of the stability of a spray-dried tuberculosis vaccine candidate designed for dry powder…
Particle engineering via spray drying was used to develop a dry powder presentation of an adjuvanted tuberculosis vaccine candidate. This presentation utilizing a trileucine-trehalose excipient system was designed to be both thermostable and suitable for respiratory delivery. The stability of the…
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Hierarchical Particle Approach for Co-Precipitated Amorphous Solid Dispersions for Use in…
Amorphous solid dispersions (ASD) have become a well-established strategy to improve exposure for compounds with insufficient aqueous solubility. Of methods to generate ASDs, spray drying is a leading route due to its relative simplicity, availability of equipment, and commercial scale capacity.…
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Insights into the Control of Drug Release from Complex Immediate Release Formulations
The kinetics of water transport into tablets, and how it can be controlled by the formulation as well as the tablet microstructure, are of central importance in order to design and control the dissolution and drug release process, especially for immediate release tablets.
This research employed…
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