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Spray drying
Evaluation of solid carvedilol-loaded SMEDDS produced by the spray drying method and a study of…
In this study, various formulations of solidified carvedilol-loaded SMEDDS with high SMEDDS loading (up to 67% w/w) were produced with the spray drying process using various porous silica-based carriers. The process yield was improved with higher atomization gas flow rate during the spray drying…
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Storage stability of inhalable, controlled-release powder formulations of ciprofloxacin…
Novel inhalable and controlled release powder formulations of ciprofloxacin nanocrystals inside liposomes (CNL) were recently developed. In the present study, the storage stability of CNL powders consisting of lyoprotectant (i.e. sucrose or lactose), lipids, ciprofloxacin (CIP), and magnesium…
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Understanding the Impact of Protein–Excipient Interactions on Physical Stability of Spray-Dried…
Mannitol, leucine, and trehalose have been widely used in spray-dried formulations, especially for inhalation formulations. The individual contribution of these excipients on protein physical stability in spray-dried solids was studied here using bovine serum albumin (BSA) as a model protein. The…
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Nanostructured micronized solid dispersion of crystalline-amorphous metronidazole embedded in…
In this study metronidazole drug was encapsulated by hydroxypropyl methylcellulose and polyvinylpyrrolidone polymers from solutions using nano spray drying technology. The influence of the process parameters and formulation variables were investigated on product morhology and structure, production…
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Mesoporous silica: a solution for amorphous stabilization of poor glass formers
Introduction: Amorphous formulation technologies to improve oral absorption of poorly soluble active pharmaceutical ingredients (APIs) have become increasingly prevalent. Currently, polymer based amorphous formulations manufactured by spray drying, hot melt extrusion (HME), or coprecipitation are…
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Impact of Crystalline and Amorphous Matrices on Successful Spray Drying of siRNA Polyplexes for…
To develop stable and inhalable dry powder formulations with long shelf life, polyplexes consisting of siRNA and a polyethylenimine (PEI)‐based block copolymer in presence of mannitol or trehalose are spray dried. The effect of inlet (T‐In) and outlet (T‐Out) temperature on the recovery of siRNA and…
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Topical cellulose nanocrystals-stabilized nanoemulgel loaded with ciprofloxacin HCl with enhanced…
Spray-dried cellulose nanocrystals (CNC) were investigated as a potential stabilizer for the preparation of nanoemulsion gels (nanoemulgels) loaded with ciprofloxacin hydrochloride to act as dual-role gels capable of stimulating the tissue regeneration as well as inhibition of microbial growth.…
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Development and Characterization of Excipient Enhanced Growth (EEG) Surfactant Powder Formulations…
This study aimed to develop and characterize a spray-dried powder aerosol formulation of a commercially available surfactant formulation, Survanta® intratracheal suspension, using the excipient enhanced growth (EEG) approach. Survanta EEG powders were prepared by spray drying of the feed dispersions…
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Progress in spray-drying of protein pharmaceuticals: Literature analysis of trends in formulation…
Spray-drying is an inherently continuous and well-established industrial drying process. It can accelerate manufacturing of biopharmaceuticals and vaccine products, resulting in both an economic and health benefit. In this review, we cover a systematic assessment and discuss the spray-drying of…
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Obtainment of the spray-dried extracts of Peperomia pellucida L. (H.B.K.) using different…
Spray-dried extracts are prepared as powders or granules after solvent removal, which can be obtained in the presence or absence of pharmaceutical adjuvants. This work aimed to optimize the process of obtaining dried extracts of Peperomia pellucida L. (HBK) by spray drying. The characterization of…
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