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Spray drying
A meticulous overview on drying-based (spray-, freeze-, and spray-freeze) particle engineering…
Drying is an indispensable operation in the preparation of pharmaceutical powders and always remained one of the energetic tasks in the pharmaceutical industry. Improving the stability, solubility, and dissolution of pharmaceutical products are being prime objectives of the drying process, intending…
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Repurposing Melt Degradation for the Evaluation of Mixed Amorphous-Crystalline Blends
Medicine regulators require the melting points for crystalline drugs, as they are a test for chemical and physical quality. Many drugs, especially salt-forms, suffer concomitant degradation during melting; thus, it would be useful to know if the endotherm associated with melt degradation may be used…
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Designing enhanced spray dried particles for inhalation: A review of the impact of excipients and…
Spray drying is a constructive single-step manufacturing technique used to produce dry powder. Spray drying plays a remarkable role in producing inhalable powder formulations due to its ability to engineer particles with optimized characteristics for inhalation. However, the complexity of drying…
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Spray Drying for Direct Compression of Pharmaceuticals
Tableting by direct compression (DC) is one of the simplest and most cost-effective drug manufacturing approaches. However, most active pharmaceutical ingredients (APIs) and excipients lack the compression and flow properties required to meet the needs of high-speed industrial tablet presses.…
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Improved Bioavailability and High Photostability of Methotrexate by Spray-Dried Surface-Attached…
Low aqueous solubility and poor bioavailability are major concerns in the development of oral solid-dosage drug forms. In this study, we fabricated surface-attached solid dispersion (SASD) to enhance the solubility, bioavailability, and photostability of methotrexate (MTX), a highly lipophilic and…
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Organic Solution Advanced Spray-Dried Microparticulate/Nanoparticulate Dry Powders of Lactomorphin…
The purpose of this study was to formulate Lactomorphin (MMP2200) in its pure state as spray-dried(SD) powders, and with the excipient Trehalose as co-spray-dried(co-SD) powders; for intranasal and deep lung administration with Dry Powder Inhalers (DPI). Lactomorphin is a glycopeptide which was…
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Effects of drying method and excipient on the structure and physical stability of protein solids:…
This study aims to determine the impacts of drying method and excipient on changes in protein structure and physical stability of model protein solids. Protein solids containing one of two model proteins (lysozyme or myoglobin) were produced with or without excipients (sucrose or mannitol) using…
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On the particle formation of leucine in spray drying of inhalable microparticles
The particle formation of L-leucine, a dispersibility-enhancing amino acid used in the spray drying of inhalable pharmaceutical aerosols, was extensively studied using three experimental methods, and the results were interpreted with the aid of theory. A comparative-kinetics electrodynamic balance…
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Spray drying of naproxen and naproxen sodium for improved tableting and dissolution –…
In this work the tabletability and dissolution of spray-dried forms of naproxen and its sodium salt were compared with those of unprocessed drugs. Solutions of naproxen or naproxen sodium alone or with HPMC (5% w/w of drug content) were spray dried. Scanning electron micrographs showed that naproxen…
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Development of a Surface Coating Technique with Predictive Value for Bead Coating in the…
The aim of this paper was to investigate whether a surface coating technique could be developed that can predict the phase behavior of amorphous solid dispersions (ASDs) coated on beads. ASDs of miconazole (MIC) and poly(vinylpyrrolidone-co-vinyl acetate) (PVP-VA) in methanol (MeOH) were studied as…
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