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Spray drying
The effects of spray drying, HPMCAS grade, and compression speed on the compaction properties of…
Spray dried dispersions (SDDs) have the potential to dramatically improve the oral bioavailability of drugs with poor water solubility. However, SDDs tend to have material attributes, such as small particle size, low bulk density, and poor flowability, which are undesirable for downstream processing…
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Spray dried VSV-vectored vaccine is thermally stable and immunologically active in vivo
Effective vaccine delivery and coverage to rural and resource-poor countries is hindered by the dependence on cold chain storage. As such, developments of cold chain-free technologies are highly sought. Although spray dried adenoviral vectors have shown long term stability at ambient temperatures…
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Spray Drying for the Preparation of Nanoparticle-Based Drug Formulations as Dry Powders for…
Nanoparticle-based therapeutics have been used in pulmonary formulations to enhance delivery of poorly water-soluble drugs, protect drugs against degradation and achieve modified release and drug targeting. This review focuses on the use of spray drying as a solidification technique to produce…
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Spray Freeze-Drying as a Solution to Continuous Manufacturing of Pharmaceutical Products in Bulk
Pharmaceutical manufacturing is evolving from traditional batch processes to continuous ones. The new global competition focused on throughput and quality of drug products is certainly the driving force behind this transition which, thus, represents the new challenge of pharmaceutical manufacturing…
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Development and characterization of curcumin-loaded solid self-emulsifying drug delivery system…
Highlights
• Soluplus® could be used as a carrier for the entrapment of SEDDS.
• Spray drying is efficient for the preparation of Solid SEDDS with Soluplus®.
• Solid SEDDS in Soluplus® exhibit comparable flow as Neusilin® based adsorbates.
• CUR-SEDDS dissolves faster when trapped…
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Multicomponent solid dispersion: A new generation of solid dispersion produced by spray-drying
The term “multicomponent solid dispersion” is widely used in recent literature to describe solid formulations consisting of a special excipient's mixture and active molecules finely dispersed. However, this term has not yet been defined. In this review, we aimed to improve the definition of…
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Zein as a water insoluble excipient for spray dry encapsulation of hydrophilic bioactives
Anti-solvent precipitation of zein was employed in conjunction with spray drying to reduce the usage of ethanol and to encapsulate the aqueous extract of green jelly leaf (Cyclea barbata Miers) antioxidants. Different concentrations of zein (0.35, 0.7, 1.05 and 1.4% w/v) and Hydroxypropylmethyl…
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Influence of Composition and Spray-Drying Process Parameters on Carrier-Free DPI Properties and…
Although dry powder inhalers (DPIs) have attracted great interest compared to nebulizers and metered-dose inhalers (MDIs), drug deposition in the deep lung is still insufficient to enhance therapeutic activity. Indeed, it is estimated that only 10–15% of the drug reaches the deep lung while 20% of…
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Spray-dried liposomes: A study of the effect of carbohydrate carrier and concentrations on liposome…
Background and objective: Dry powder inhalation provide many promising features for
drug delivery to the pulmonary system, such as localization of drug within the lungs, drug
retention in the respiratory tract, and reduced systemic toxicities. This study aimed to
prepare dry powders of liposomes…
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Advanced Tablet Coating Development: Applying Optical Coherence Tomography (OCT) as a PAT Tool for…
Purpose: Novel tablet coating approaches include the development of continuous coating technologies. This requires a high level of automation to assure the quality and safety of the final coated product. Despite automation of control procedures also approaches of in-line process analytical…
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