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Spray drying
Efavirenz dissolution enhancement III: Colloid milling, pharmacokinetics and electronic tongue…
03. January 2017
Abstract
Efavirenz (EFV), a non-nucleoside reverse transcriptase inhibitor (NNRTI), is part of first-line therapy for the treatment of human immunodeficiency virus type 1 infection (HIV-1/AIDS). This drug shows relatively low oral absorption and bioavailability, as…
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Microencapsulated SLN: An innovative strategy for pulmonary protein delivery
Abstract
Associating protein with nanoparticles is an interesting strategy to improve their bioavailability and biological activity. Solid lipid nanoparticles (SLN) have been sought as carriers for therapeutic proteins transport to the lung epithelium. Nevertheless, because of their low…
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Spray-dried amorphous isomalt and melibiose, two potential protein-stabilizing excipients
20. June 2016
Abstract
The possibility of producing amorphous isomalt and melibiose by spray drying was studied. The impact of process parameters on yield and solid-state stability was compared to sucrose and trehalose. All powders remained amorphous during 2–3 weeks. Processing was…
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Evaluation of excipients for enhanced thermal stabilization of a human type 5 adenoviral vector…
01. May 2016
We have produced a thermally stable recombinant human type 5 adenoviral vector (AdHu5) through spray drying with three excipient formulations (l-leucine, lactose/trehalose and mannitol/dextran). Spray drying leads to immobilization of the viral vector which is believed to prevent…
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AN INVESTIGATION INTO TASTE MASKING OF A MICRONIZEDPARACETAMOL USING AQUACOAT® ECD APPLIED VIA…
INTRODUCTION AND PURPOSE
Taste masking is a very important step in the development of paediatric medications such as oral suspensions and tablets for products with APIs that are bitter or unpalatable. In this study, taste masking of a bitter, micronized API model (Paracetamol) was…
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Spray drying of nanoparticles to form fast dissolving glipizide – Article
Poor water solubility of pharmaceutical candidates creates a big barrier to development and clinical applications. In this study, glipizide as a poorly water soluble drug was precipitated as nanoparticles and processed by spray drying to produce fast dissolving powders. Nanosuspensions of…
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Capsugel Advances the First Intrinsically Enteric Capsule Technology
Capsugel is a global leader in delivering high-quality, innovative dosage forms and solutions to its customers in the health care industry. The company’s Hard Capsule business unit offers customers the broadest portfolio of gelatin, vegetarian and other specialized capsule…
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