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Stabilizer
Development and Stability of a New Formulation of Pentobarbital Suppositories for Paediatric…
Pentobarbital is a drug of choice to limit motion in children during paediatric procedural sedations (PPSs). However, despite the rectal route being preferred for infants and children, no pentobarbital suppositories are marketed, and therefore they must be prepared by compounding pharmacies. In this…
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Overcoming Challenges in Ophthalmic Formulations through Polymer Selection
Ophthalmic drugs are delivered to the eye to treat chronic diseases such as dry eye and acute conditions such as inflammation and infections.
The market for drugs administered to the eye is growing, in large part, due to our aging population and the increased prevalence of eye-related conditions…
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Development of Mefenamic Acid-Soluplus® amorphous dispersions via hot melt extrusion and in silico…
The objective of this study was to increase the solubility of Mefenamic Acid (MA), a BCS class II drug by formulating amorphous solid dispersions via Hot-Melt Extrusion. The extrudates were prepared at different drug to polymer ratios and characterised by standard analytical techniques. Dissolution…
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Amorphous Solid Dispersions Layered onto Pellets – An Alternative to Spray Drying?
Spray drying is one of the most frequently used solvent-based processes for manufacturing amorphous solid dispersions (ASDs). However, the resulting fine powders usually require further downstream processing when intended for solid oral dosage forms. In this study, we compare properties and…
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Trehalose in Biomedical Cryopreservation–Properties, Mechanisms, Delivery Methods, Applications,…
Cells and tissues are the foundation of translational medicine. At present, one of the main technological obstacles is their preservation for long-term usage while maintaining adequate viability and function. Optimized storage techniques must be developed to make them safer to use in the clinic.…
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Fabrication of Celecoxib PVP Microparticles Stabilized by Gelucire 48/16 via Electrospraying for…
Electrospraying (ES) technology is considered an efficient micro/nanoparticle fabrication technique with controlled dimensions and diverse morphology. Gelurice® 48/16 (GLR) has been employed to stabilize the aqueous dispersion of Celecoxib (CXB) for enhancing its solubility and oral bioavailability.…
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Engineered Lipid Excellence For Topical Applications – IOI Oleo
Tried & Trusted, Quality & Innovation
With our nature-based excipients you can develop modern pharmaceutical topical formulations that combine functionality, regulatory compliance and a pleasant skin feel. While the advantages of localized drug delivery for acute conditions are clear, the…
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Stability of APIs in Super Refined Oils – Maximise the Performance of Your Active…
Discover the Benefits of Super Refined Excipients
Excipient choice can make all the difference in successful formulation development. The selection of pharmaceutical excipients in a drug formulation can have a significant impact on development timescales, Active Pharmaceutical Ingredient (API)…
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Randomized clinical study of injectable dextrin-based hydrogel as a carrier of a synthetic bone…
Abstract
Objectives
This study aimed to improve the performance and mode of administration of a glass-reinforced hydroxyapatite synthetic bone substitute, Bonelike by Biosckin® (BL®), by association with a dextrin-based hydrogel, DEXGEL, to achieve an injectable and moldable device named DEXGEL…
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Advancing oral delivery of biologics: Machine learning predicts peptide stability in the…
The oral delivery of peptide therapeutics could facilitate precision treatment of numerous gastrointestinal (GI) and systemic diseases with simple administration for patients. However, the vast majority of licensed peptide drugs are currently administered parenterally due to prohibitive peptide…
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