Stabilizer

Oral tadalafil (TD) proved promising in treating pediatric pulmonary arterial hypertension (PAH). However, to ensure higher efficacy and reduce the systemic side effects, targeted delivery to the lungs through nebulization was proposed as an alternative approach. This poorly soluble drug was…
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Two Polyvinyl Alcohol Grades Providing Excellent Performance for Solubility Enhancement and Stabilization Poor solubility of APIs is a critical challenge in drug development. One formulation technique to address this challenge is hot melt extrusion (HME). Mercks Parteck® MXP range of polymers…
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An approach to differentially modify the internal surface of porous silicon nanoparticles (pSiNPs) with hydrophobic dodecene and the external surface with antifouling poly-N-(2-hydroxypropyl) acrylamide (polyHPAm) as well as a cell-targeting peptide was developed. Specifically, to generate these…
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Orally disintegrating tablets are an emerging trend in novel drug delivery system and have received ever increasing demand during the last few decades. Orally disintegrating tablets ODTs are the dosage form which will disintegrate in mouth within seconds without need of water. This type of property…
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Florham Park, New Jersey, December 5, 2022 – BASF Pharma Solutions, a global business unit of BASF, announces today that the U.S. Food and Drug Administration (FDA) Center for Drug Evaluation and Research (CDER), Office of New Drugs, has accepted their excipient, Soluplus®, into the FDA’s Pilot…
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COVID-19 is caused by the infection of the lungs by SARS-CoV-2. Monoclonal antibodies, such as sotrovimab, showed great efficiency in neutralizing the virus before its internalization by lung epithelial cells. However, parenteral routes are still the preferred route of administration, even for local…
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In situ amorphization is a promising approach, considered in the present work, to enhance the solubility and dissolution rate of olanzapine, while minimizing the exposure of the amorphous material to the stress conditions applied during conventional processing. The production of pellets by…
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Transepidermal microneedle-assisted drug delivery is an alternative approach that can improve the therapeutic permeability of the drug in the deeper layers of the skin. The project aims to check the effect of a microneedle roller on transepidermal delivery of Iloperiodone across the neonatal porcine…
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Film-coating agent formulated without TiO2, aluminium and artificial colors Current solutions in tablet coating make it hard to both meet the growing demand for naturalness from consumers and to comply with stricter regulations, especially in Europe. SEPIFILM™ NATurally COLored by Seppic are…
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Quality for your formulation, stability for your products. To solve the challenge of stability requirements in plasma applications, we offer a wide range of high-quality pharmaceutical excipients that allow you to formulate and manufacture stable plasma products. These include pH…
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