Stabilizer

Polysorbate excipients are commonly used as surfactants to stabilize therapeutic proteins in formulations. Degradation of polysorbates could lead to particle formation and instability of the drug formulation. We investigated how the fatty acid composition of polysorbate 80 impacts the degradation…
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The multi-drug resistance of Pseudomonas aeruginosa is an overwhelming cause of terminal and persistent lung infections in cystic fibrosis (CF) patients. Antimicrobial synergy has been shown for colistin and ivacaftor, and our study designed a relatively high drug-loading dry powder inhaler …
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Enteric infections have long constituted a silent epidemic responsible for hundreds of thousands of deaths around the world every year. Because of the global rise in antibiotic-resistant bacteria and the slow development of new small-molecule antibiotics, alternatives such as bacteriophage therapy…
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There is much interest in converting poorly water-soluble drugs into nanocrystals as they provide extremely high surface area that increases dissolution rate and oral bioavailability. However, nanocrystals are prepared as aqueous suspensions, and once the suspensions are dried for development of…
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Objective To provide a basis for the selection of suitable emulsifiers in oil-in-water emulsions used as tissue analogs for MRI experiments. Three different emulsifiers were investigated with regard to their ability to stabilize tissue-like oil-in-water emulsions. Furthermore, MR signal properties…
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Discover Gattefossé's brand new excipient Emulfree® Duo, a ready-to-use stabilizing agent, enabler of bi-gel, an emerging topical dosage form. Bi-gels consist of an intimate mixture of aqueous and oily gels. Thanks to their dual nature, they are associated with better drug absorption through the…
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Highlights • Ester functionalized surface active ionic liquids were synthesized. • Biodegradable and biocompatible catanionic vesicles were prepared. • Analytical techniques were used to study the structure of catanionic vesicles. • Small angle neutron scattering was used to…
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The current study is aimed at the development of chrono modulated multiple unit particulate systems (MUPS) of nifedipine (ND) by a continuous double extrusion process. ND, a poorly soluble drug, was formulated into an amorphous solid dispersion (ASD) to improve its solubility. Further, the ASD was…
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Nanocrystal formulations of the BCS class II agomelatine, were developed by wet media milling. The most suitable stabilizer was identified and effects of process and formulation variables on the nanocrystal size and ζ-potential were evaluated employing a Box-Behnken experimental design. The…
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Shield your protein of interest from challenging conditions throughout the manufacturing process and increase shelf life with Merck's high purity stabilizers. Learn how you can minimize regulatory and quality-associated risks in your biopharmaceutical manufacturing. Stabilizers – for biomolecule…
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