Browsing Category
Stabilizer
Enhancing the Stabilization Potential of Lyophilization for Extracellular Vesicles
Extracellular vesicles (EV) are an emerging technology as immune therapeutics and drug delivery vehicles. However, EVs are usually stored at −80 °C which limits potential clinical applicability. Freeze-drying of EVs striving for long-term stable formulations is therefore studied. The most…
Read More...
Read More...
Lyophilization Preserves the Intrinsic Cardioprotective Activity of Bioinspired Cell-Derived…
Recently, bioinspired cell-derived nanovesicles (CDNs) have gained much interest in the field of nanomedicine due to the preservation of biomolecular structure characteristics derived from their parent cells, which impart CDNs with unique properties in terms of binding and uptake by target cells and…
Read More...
Read More...
GE11 Modified PLGA/TPGS Nanoparticles Targeting Delivery of Salinomycin to Breast Cancer Cells
Abstract:
Salinomycin (Sal) is a potent inhibitor with effective anti-breast cancer properties in clinical therapy. The occurrence of various side effect of Sal greatly limits its application. The epidermal growth factor receptor (EGFR) family is a family of receptors highly expressed in most…
Read More...
Read More...
Effect of Poly(trehalose methacrylate) Molecular Weight and Concentration on the Stability and…
Instability to storage and shipping conditions and injection administration remain major challenges in treating chronic conditions with biopharmaceuticals. Herein, formulations of poly(trehalose methacrylate) (pTrMA) are successfully optimized to stabilize insulin without appreciably increasing…
Read More...
Read More...
Seppic injectable polysorbates Montanox™ 80 PPI and Montanox™ 20 PPI are now compliant in the…
Montanox™ 80 PPI and Montanox™ 20 PPI, ingredients developed and produced by Seppic, comply with the current Chinese pharmacopoeia and will be marketed in China from May 2021.
As a supplier of specialty healthcare ingredients, Seppic is active in the parenteral excipients market with various…
Read More...
Read More...
New Kolliphor® P188 Bio from BASF
Parenteral grade surfactant designed for stabilizing biologic formulations
Biologic formulations require the most stringent requirements to be met in order to ensure patient safety and the optimal performance of the drug. Poloxamer 188 has a long history of use in approved and marketed biologic…
Read More...
Read More...
Topical cellulose nanocrystals-stabilized nanoemulgel loaded with ciprofloxacin HCl with enhanced…
Spray-dried cellulose nanocrystals (CNC) were investigated as a potential stabilizer for the preparation of nanoemulsion gels (nanoemulgels) loaded with ciprofloxacin hydrochloride to act as dual-role gels capable of stimulating the tissue regeneration as well as inhibition of microbial growth.…
Read More...
Read More...
Carboxymethyl-β-glucan/chitosan nanoparticles: new thermostable and efficient carriers for antigen…
In the last few decades, nanotechnology has emerged as an important tool aimed at enhancing the immune response against modern antigens. Nanocarriers designed specifically for this purpose have been shown to provide protection, stability, and controlled release properties to proteins, peptides, and…
Read More...
Read More...
Influence of drug-carrier compatibility and preparation method on the properties of…
The main objective of this paper is to elucidate the influence of drug-carrier compatibility and preparation method on the properties of Paclitaxel (PTX)-loaded lipid liquid crystalline nanoparticles (LLCNs). Here, glyceryl monooleate (GMO), glycerol monolinoleate (GML), glyceryl monolinolenate…
Read More...
Read More...
Preparation and evaluation of a water-in-oil nanoemulsion drug delivery system loaded with…
Salidroside (SAL) is a phenolic substance with high solubility and low permeability, which make it easy to cause the efflux effect of P-glycoprotein and degradation of intestinal flora, resulting in lower bioavailability. The aim of this study was to develop and optimize a water-in-oil nanoemulsion…
Read More...
Read More...