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Stabilizer
Formulation and Optimization of Atovaquone Micronized Suspension by Top-down Method
Aim: The present work aimed to tackle the solubility issue of a Biopharmaceutics Classification System (BCS) II drug, Atovaquone.
Methods: Formulation of micronized suspension of atovaquone was optimized by employing a 32 full factorial design keeping poloxamer 188 (wetting agent) and…
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Generation of Ophthalmic Nanosuspension of Prednisolone Acetate Using a Novel Technology
Purpose
Prednisolone Acetate (PAC) is currently marketed as micronized ophthalmic suspension. The microsuspension has poor dose accuracy and efficacy due to aggregation, slow dissolution rate and limited corneal residence. The ophthalmic nanosuspension of PAC shall show enhanced solubility,…
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Formulation and stability study of hydroxychloroquine sulfate oral suspensions
Hydroxychloroquine is an antimalarial drug indicated in the treatment of acute attacks of malaria due to Plasmodium vivax, P. malariae, P. ovale, and susceptible strains of P. falciparum. It is also used for the treatment of rheumatoid arthritis, discoid and systemic lupus erythematosus, and more…
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Co-processing of small molecule excipients with polymers to improve functionality
Introduction
Polymers have various applications such as binder, film coating agent, stabilizer, drug release modification and as primary packaging materials. Recently, they have been explored in co-processing technique to improve the functionality of small molecule excipients (SMEs). Co-processing…
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Stability properties and antioxidant activity of curcumin nanosuspensions in emulsion systems
In this study, curcumin nanosuspensions (Cur-NSs) were prepared using D-alpha-tocopheryl polyethylene glycol succinate (vitamin E TPGS), and their physical properties (i.e., particle size, dispersion stability) were investigated. Also, the antioxidant activity of Cur-NSs in emulsion systems was…
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Solubility and Stability Enhanced Oral Formulations for the Anti-Infective Corallopyronin A
Novel-antibiotics are urgently needed to combat an increase in morbidity and mortality due to resistant bacteria. The preclinical candidate corallopyronin A (CorA) is a potent antibiotic against Gram-positive and some Gram-negative pathogens for which a solid oral formulation was needed for further…
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Storage stability of proteins in a liquid-based formulation: liquid vs. solid self-emulsifying drug…
The objective of the present study was the development of self-emulsifying drug delivery systems (SEDDS) for oral delivery of therapeutic proteins providing storage stability. Horseradish peroxidase (HRP) serving as model protein was ion paired with docusate and incorporated into three liquid and…
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Polymer structure and property effects on solid dispersions with haloperidol: poly(N-vinyl…
Poly(2-methyl-2-oxazoline) (PMOZ), poly(2-propyl-2-oxazoline) (PnPOZ) and poly(2-isopropyl-2-oxazoline) (PiPOZ) were synthesized by hydrolysis of 50 kDa poly(2-ethyl-2-oxazoline) (PEOZ) and subsequent reaction of the resulting poly(ethylene imine) with acetic, butyric and isobutyric anhydrides,…
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Hand sanitizer virucidal testing, excipients and formulation information by SEPPIC
Seppic has confirmed through external testing the virucidal activity* of below hydroalcoholic gel formulas according to the EN 14476 standard.
* virucidal against enveloped viruses (Modified vaccinia virus Ankara), virucidal with limited spectrum activity (Adenovirus Type 5, Murine norovirus), 30…
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Functionalised calcium carbonate as a coformer to stabilize amorphous drugs by mechanochemical…
The aim of this study was to investigate the amorphization, physical stability and drug release of a model drug, carvedilol (CAR), when loaded onto functionalised calcium carbonate (FCC) using mechanochemical activation (vibrational ball milling). The solid-state characteristics and physical…
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