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Stabilizer
Effect of the third component on the aging and crystallization of cinnarizine-soluplus® binary solid…
Multiple carriers may be used to prepare solid dispersions (SDs) for different purposes. The aim of this work is to investigate the effect of the third component on the physical stability and physical aging behavior of cinnarizine-soluplus SDs. HPMC, PVP, sorbitol and citric acid were used as the…
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Cyclodextrin Based Nanoparticles for Drug Delivery and Theranostics
Colloidal nanoparticulate technology has been described in the literature as a versatile drug delivery system. But it possesses some inherent lacunae in their formulation. Cyclodextrins (CDs) have been extensively reported for the solubility enhancement of poorly water-soluble drugs.
The CDs can…
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Design and Synthesis of Polymer Prodrugs for Improving Water-Solubility, Pharmacokinetic Behavior…
Purpose
TXA9, a novel cardiac glycoside, has a potent anti-proliferative effect against A549 human lung cancer cells, however, possesses a poor water-solubility and a rapid metabolic rate in vivo which limited the further development of TXA9. To overcome the shortcomings of TXA9, four polymer…
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Evaluation of the stability and absorption of tacrolimus self-microemulsifying drug delivery system
Tacrolimus (FK506) is one of the most usually used drugs for organ transplantation. The poor bioavailability of FK506 is mainly caused by its low solubility, which can be improved by the application of self-microemulsifying drug delivery system (SMEDDS). This study was focused on the evaluation of…
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Novel approach for overcoming the stability challenges of lipid-based excipients. Part 1: Screening…
The major challenge of conventional lipid-based excipients (LBE) for drug delivery is their unstable solid state, affecting the stability of pharmaceutical product. Polyglycerol esters of fatty acids (PGFAs) are oligomeric hydroxyethers of glycerol fully or partially esterified with fatty acids.…
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A Comparative Study of the Effect of Different Stabilizers on the Critical Quality Attributes of…
Lamivudine (3TC) and zidovudine (AZT) are antiviral agents used orally to manage HIV/AIDS infection. A pseudo one-solvent bottom-up approach was used to develop and produce nano co-crystals of 3TC and AZT. Equimolar amounts of 3TC dissolved in de-ionized water and AZT in methanol were rapidly…
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Emerging role of nanosuspensions in drug delivery systems
Rapid advancement in drug discovery process is leading to a number of potential new drug candidates having excellent drug efficacy but limited aqueous solubility.
By virtue of the submicron particle size and distinct physicochemical properties, nanosuspension has the potential ability to tackle…
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Excipients in freeze-dried biopharmaceuticals: Contributions toward formulation stability and…
Biopharmaceuticals are one of the fastest growing areas within the pharmaceutical industry.
As protein drugs require parenteral administration, they are commonly formulated as aqueous solutions. However, this is not always feasible due to their general instability. In such cases, lyophilised…
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High purity excipients – A Simple Solution to a Complex Problem
A drug-dev.com article by Dr. William Small and Arsalan Khan
It wouldn’t come as a surprise to anyone that active pharmaceutical ingredients (APIs) come in a wide variety. Small molecule, large molecule, peptide, monoclonal antibody, innovative, generic; the list goes on. These molecules have the…
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Insights on the Formulation of Recombinant Proteins
Recombinant proteins are large and complex molecules, whose therapeutic activity highly depends on their structure.
Formulation of biopharmaceuticals aims at stabilizing protein conformation, promoting its efficacy, and preventing safety concerns, such as immunogenicity. Currently, the rational…
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