Browsing Category
Stabilizer
The Optimization Design Of Lactoferrin Loaded HupA Nanoemulsion For Targeted Drug Transport Via…
Huperzine A (HupA) is a selective acetylcholinesterase inhibitor used to treat Alzheimer’s disease. The existing dosage of HupA lacks brain selectivity and can cause serious side effects in the gastrointestinal and peripheral cholinergic systems.
Purpose
The aim of this study was to develop and…
Read More...
Read More...
Novel Surfactant Excipient Significantly Improves Biologic Stability in Liquid Formulation
As you maybe aware, polysorbates present a host of challenges for stabilizing biopharmaceuticals due to their own stability issues. To adress this, DuPont Pharma Solutions developed a new surfactant, an experimental material called FM1000!
WATCH THE VIDEO HERE TO GET INFORMED!
Joshua…
Read More...
Read More...
Effect of Stabilizers on Encapsulation Efficiency and Release Behavior of Exenatide-Loaded PLGA…
The aim of this study was to investigate the effects of various stabilizers on the encapsulation efficiency and release of exenatide-loaded PLGA (poly(lactic-co-glycolic acid)) microspheres prepared by the water-in-oil-in-water (W/O/W) solvent evaporation (SE) method.
It was shown that the…
Read More...
Read More...
Catalpol and Mannitol, Two Components of Rehmannia glutinosa, Exhibit Anticonvulsant Effects…
Epilepsy is a brain disorder that affects millions of people worldwide and is usually managed using currently available antiepileptic drugs, which result in adverse effects and are ineffective in approximately 20-25% of patients.
Thus, there is growing interest in the development of new…
Read More...
Read More...
Amino acids as stabilizers for spray-dried simvastatin powder for inhalation
Background
The use of amino acids as excipients is a promising approach to improve the physical stability and powder dispersibility of spray-dried powders for inhalation.
Objectives
The aim of this study was to investigate the stabilizing effect of different amino acids on spray-dried…
Read More...
Read More...
A wet-milling method for the preparation of cilnidipine nanosuspension with enhanced dissolution and…
Cilnidipine (CLD) is extensively used in the treatment of hypertension; however, it has extremely low solubility which limits its clinical application.
The purpose of the present research was to improve the dissolution rate and oral bioavailability of CLD by preparing a nanosuspension. The CLD…
Read More...
Read More...
Opportunities for Successful Stabilization of Poor Glass-Forming Drugs: A Stability-Based Comparison…
Amorphous formulation technologies to improve oral absorption of poorly soluble active pharmaceutical ingredients (APIs) have become increasingly prevalent.
Currently, polymer-based amorphous formulations manufactured by spray drying, hot melt extrusion (HME), or co-precipitation are…
Read More...
Read More...
Comparison of Proprietary and 3 Generic Formulation of Propofol for Induction of General Anesthesia
Background: This study compared the properties of propofol bolus for induction of general anesthesia between proprietary and 3 generic formulations, to assess if solvent differences had clinically relevant consequences on efficacy or side effects. Many studies have investigated different…
Read More...
Read More...
Excipients for Parenteral Use
Discover BASF’s wide range of excipients for parenteral use meeting the highest quality standards as well as BASF’s unparalleled experience in quality and regulatory affairs.
Click on the poster for a full view:
PDF Download: EXCIPIENTS FOR PARENTERAL USE
More about BASF Pharmaceutical…
Read More...
Read More...
Semi-Solid Topical Formulary
Topical formulations may be used to deliver active pharmaceutical ingredients (APIs) to or through the skin. These formulations typically possess a relatively soft, spreadable consistency and are often formulated as either water-in-oil or oil-in-water emulsions.
BASF offers an unparalleled…
Read More...
Read More...