Stabilizer

The molecular interactions between compound and polymeric carriers are expected to highly contribute to high drug load and good physical stability of solid dispersions. In this study, a series of amorphous solid dispersions (ASD) of Curcumin (Cur) were prepared with different polymers by the…
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Background Renal cell carcinomas (RCC) harboring a TFE3 gene fusion (TfRCC) represent an aggressive subset of kidney tumors. Key signaling pathways of TfRCC are unknown and preclinical in vivo data are lacking. We investigated Akt/mTOR pathway activation and the preclinical efficacy of dual…
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Curcuminoids have been long proven to possess antioxidant, anti-inflammatory and antibacterial properties which are crucial in their role as a pharmacological active agent. However, its poor solubility, high oxidative degradation, light sensitivity and poor bioavailability have been huge hurdles…
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Kollidon® 30 is the solution for endless opportunities in pharmaceutical formulations – use it as a binder, pore former, stabilizer, thickener, solubilizing agent, crystallization inhibitor and countless more. Click on the poster to see it in bigger size. PDF DOWNLOAD: KOLLIDON® 30 More…
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Polyvinylpyrrolidone includes soluble and insoluble grades; soluble grades are synthesised by the mechanism of polymerization, the free radical polymerization into water by using hydrogen peroxide as an initiator, the mechanism which terminates the polymerisation reaction makes it probable to…
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Kollidon® SR-based matrix formulations are well known for obtaining strong sustained release functionality. Depending on the solubility of the active ingredient and the required dissolution profile, pore formers need to be added for adjusting drug release. This work was to investigate the maximum…
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The most important properties of promising drug candidates for oral dosage form are aqueous solubility and intestinal permeability. Over 40% of drugs on the market are BCS class II and IV, which have low solubility. Furthermore, new chemical entities are even less soluble compared to marketed…
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Clopidogrel bisulfate (CB) is a golden antiplatelet treatment, yet its benefits are limited by its low bioavailability (<50%) caused by poor intestinal solubility and absorption. The present study aims to improve CB intestinal solubility and absorption through developing a novel stable dry CB…
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Calcium alginate beads loaded with Mg(OH)2 improve L. casei viability under simulated gastric condition Alginate beads are commonly used for protection of probiotics against adverse environmental conditions. However, alginate beads are unable to provide complete cell viability under stringent…
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Vitamin E TPGS, a water soluble derivative of natural Vitamin E, is a multirole excipient for pharmaceutical drug delivery innovation. Vitamin E TPGS is a non-ionic surfactant used as: solubilizer of poorly soluble drugs absorption enhancer emulsifier vehicle for lipid-based drug…
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