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Stabilizer
Scale-up of Pharmaceutical Spray Drying Using Scale-up Rules
Spray drying is one of the widely used manufacturing processes in pharmaceutical industry. While there are voluminous experimental studies pertaining to the impact of various process–formulation parameters on the quality attributes of spray dried powders such as particle size, morphology, density,…
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Pharmacokinetic Properties of Acetyl Tributyl Citrate, a Pharmaceutical Excipient
Acetyl tributyl citrate (ATBC) is an (the Food and Drug Administration) FDA-approved substance for use as a pharmaceutical excipient. It is used in pharmaceutical coating of solid oral dosage forms such as coated tablets or capsules. However, the information of ATBC on its pharmacokinetics is…
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Excipient selection for thermally stable enveloped and non-enveloped viral vaccine platforms in dry…
Two enveloped viral vectors, vesicular stomatitis virus and influenza virus, and a non-enveloped viral vector, human adenovirus type 5, were encapsulated by spray drying to enhance thermal stability. Results with these candidates led to the hypothesis that stability performance of chosen excipients…
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Case Studies on Lipid Excipients
If you need technical information and practical tips to formulate with your lipid excipients, Gattefossé has prepared different case studies for download after registration.
How to obtain sustained release tablets of metformin hydrochloride by direct compression?
The aim was to develop dual SR…
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Current Developments in Excipient Science – Implication of Quantitative Selection of Each…
Implication of Quantitative Selection of Each Excipient in Product Development
Excipients’ role in designing different dosage forms does not require any introduction. These are the additives that are added to the formulation along with pharmacologically active substance. The main purpose of adding…
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Interpolymer complexes of Carbopol® 971 and poly(2-ethyl-2-oxazoline): physicochemical studies of…
Carbopol® 971 and poly(2-ethyl-2-oxazoline) form hydrogen-bonded interpolymer complexes in aqueous solutions and their complexation is strongly dependent on solution pH. This work investigated the complexation between these polymers in aqueous solutions. The compositions of interpolymer complexes as…
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Mannitol
Mannitol is classified as a sugar alcohol and is derived from a sugar (mannose) by reduction. Other widely known polyols are xylitol and sorbitol. Mannitol and sorbitol are isomers, differing only in the orientation of the hydroxyl group on carbon two. The physical properties of mannitol make it…
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Sucrose
Sucrose is a non-reducing crystalline disaccharide made up of glucose and fructose, found in many plants but extracted as ordinary sugar mainly from sugar cane and sugar beets. Pfanstiehl Brand, High Purity Low Endotoxin Sucrose is used in the biopharmaceutical industry to stabilize proteins,…
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Integrating the drug, disulfiram into the vitamin E-TPGS-modified PEGylated nanostructured lipid…
The ‘repurposed drug,’ disulfiram (DSF), is an inexpensive FDA-approved anti-alcoholism drug with multi-target anti-cancer effect. However, the use of DSF in clinical settings remains limited due to its high instability in blood. In the present study, we created nanostructured lipid carriers (NLC)…
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Trehalose
Trehalose is a non-reducing disaccharide consisting of two glucose molecules linked by an α, α–1,1 bond. Pfanstiehl Brand, High Purity Low Endotoxin Trehalose is used in the biopharmaceutical industry to stabilize proteins, lipids, and carbohydrates throughout the formulation and freeze/thaw life…
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