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Stabilizer
ReForm Biologics Announces New Patent on Surfactant Replacement Excipients to Stabilize…
11. July 2018
New surfactant replacement offers a promising alternative to polysorbates for stabilizing proteins
CAMBRIDGE, Mass. – July 11, 2018 – ReForm Biologics, a pharmaceutical technology company developing innovative biologic formulations to improve drug delivery…
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Are Excipients Inert? Phenytoin Pharmaceutical Investigations with New Incompatibility Insights
The U.S. Pharmacopeia defines excipients as substances other than the active pharmaceutic ingredient (API) that are added in a drug delivery system in order to aid in the manufacturing process and enhance stability, bioavailability, safety, effectiveness and delivery of the drug. The 1968…
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Stabilization of Glucagon by Trehalose Glycopolymer Nanogels
23. January 2018
Abstract
Glucagon is a peptide hormone used for the treatment of hypoglycemia; however, its clinical potential is limited by its insolubility and instability in solution. Herein, the encapsulation, stabilization, and release of glucagon by trehalose glycopolymer…
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Stability-Enhanced Ternary Solid Dispersions with HPMC and Soluplus
24. September 2017
Abstract
The aim of this study was to evaluate a novel combination of hydroxypropyl methylcellulose phthalate (HPMCP-HP-50) and Soluplus®polymers for enhanced physicochemical stability and solubility of the produced amorphous solid dispersions (ASDs). This was…
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Molecular characterization of excipients’ preferential interactions with therapeutic monoclonal…
09. August 2017
Objectives
This study reports global and local monoclonal antibody (mAb)–excipient interactions and the resulting thermodynamic and stabilization effects.
Methods
Molecular dynamics simulations are applied to quantify the interactions of key excipients…
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Mechanism-based selection of stabilization strategy for amorphous formulations: Insights into…
19. April 2017
Abstract
We developed a step-by-step experimental protocol using differential scanning calorimetry (DSC), dynamic vapour sorption (DVS), polarized light microscopy (PLM) and a small-scale dissolution apparatus (μDISS Profiler) to investigate the mechanism (solid-to-solid…
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Bilateral Effects of Excipients on Protein Stability: Preferential Interaction Type of Excipient and…
16. April 2017
Purpose
Understanding the mechanism of protein-excipient interaction and illuminating the influencing factors on protein stability are key steps in the rational design of protein formulations. The objective of this study was to assess effects of preferential…
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Hot-melt sub- and outercoating combined with enteric aqueous coating to improve the stability of…
03. January 2017
Abstract
Aspirin is apt to hydrolyze. In order to improve its stability, a new method has been developed involving the application of hot-melt sub- and outercoating combined with enteric aqueous coating. The main aim was to investigate the influence of these…
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Complication with Order: Understanding the Structure-Property Relationship of Polymers for their…
09. November 2016
Complication with Order: Understanding the Structure-Property Relationship of Polymers for their Application in Drug Delivery
In modern pharmaceutical dosage form design, excipients play a central role in delivering the drug in a safe and effective manner.…
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POTENTIAL USE OF ETHYLENE VINYL ACETATE COPOLYMER EXCIPIENT IN ORAL CONTROLLED RELEASE APPLICATIONS:…
09. November 2016
Ethylene vinyl acetate (EVA) copolymer has a record of successfully serving the pharmaceutical industry as a controlled release excipient. EVA has shown excellent stability, processability and versatility in the controlled release of selected oral…
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