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Stabilizer
The effect of a lipid composition and a surfactant on the characteristics of the solid lipid…
Abstract
Solid lipid microparticles (SLM) were produced by produced by a two-step process that, firstly, involved the emulsification of the molten lipid phase in a heated aqueous phase and, secondly, the system cooling. Compritol 888 ATO and Precirol ATO 5, including their…
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Trehalose monooleate: a potential anti- aggregation agent for stabilization of proteins
18. October 2016
Protein aggregation is a major problem of therapeutic proteins because aggregation decreases their therapeutic activity, shelf life and induces immunogenicity. Stabilization against aggregation is commonly attained by addition of different excipients like sugars,…
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Multiple-unit tablet of probiotic bacteria for improved storage stability, acid tolerability, and in…
28. April 2016
Abstract: The aim of this study was to formulate probiotics-loaded pellets in a tablet form to improve storage stability, acid tolerability, and in vivo intestinal protective effect. Bacteria-loaded pellets primarily prepared with hydroxypropyl methylcellulose…
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Surfactants in Biopharmaceuticals – AAPS Blog
13. April 2016
By Hanns-Christian Mahler and Satish K. Singh
Polysorbates (PS) (or surfactants in general) are commonly added to biopharmaceuticals as stabilizers against interface-mediated stresses. They are recognized as critical excipients by the industry as well as…
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Compatibility of 10 different APIs in SyrSpend SF PH4 oral suspensions
30. March 2016
Objectives: The objective of this study was to evaluate the compatibility of 10 commonly used active pharmaceutical ingredients (APIs) compounded in oral suspensions using a globally available suspending vehicle (SyrSpend SF PH4 liquid): caffeine 10.0 mg/mL,…
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S-protected thiolated hydroxyethyl cellulose (HEC): novel mucoadhesive excipient with improved…
08. March 2016
The aim of this study was the design of novel S-protected thiolated hydroxyethyl cellulose (HEC) and the assessment of its mucoadhesive properties and biodegradability compared to the corresponding unmodified polymer. Thiolated HEC was S-protected via disulfide bond…
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Spray drying of nanoparticles to form fast dissolving glipizide – Article
Poor water solubility of pharmaceutical candidates creates a big barrier to development and clinical applications. In this study, glipizide as a poorly water soluble drug was precipitated as nanoparticles and processed by spray drying to produce fast dissolving powders. Nanosuspensions of…
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Trehalose: A Powerful Excipient in the Formulation Toolbox – Product Information
By: Ben Nelson, PhD, and Chris Wilcox
Trehalose is a non-reducing disaccharide consisting of two glucose molecules linked by an α,α–1,1 glycosidic bond. In the pharmaceutical industry, products that benefit from the stabilizing effects of trehalose include, but are not limited…
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A Self-microemulsifying Drug Delivery System (SMEDDS) for a Novel Medicative Compound Against…
08. February 2015
AJS is the code name of an untitled novel medicative compound synthesized by the Tasly Holding Group Company (Tianjin, China) based on the structure of cinnamamide, which is one of the Biopharmaceutics Classification System (BCS) class II drugs. The drug has…
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Omyapharm – a new multifunctional mineral based excipient presented at ExcipientFest Europe…
25. May 2014
This innovative functionalized mineral based excipient for pharmaceuticals will be presented at ExcipientFest Europe showing its performance and capabilities in
• Immediate release ODTs (Orally Disintegrating Tablets) formulations
• Controlled release…
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