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Stabilizer
A Comprehensive Scientific Survey of Excipients Used in Currently Marketed, Therapeutic Biological…
Purpose
The steady development of biotechnology-derived therapeutic biologics over the last few decades has generated drugs that are now standard medical treatments for a range of indications. While the development of protein products has surged in recent years, the formulation and delivery of…
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Accelerating Topical Drug Development Through Initial Excipient Selection
See the poster presented by Seppic at DDF Summit in Berlin in June 2023:
Introduction
Novel topical drug development will require multiple formulation adjustments from the initial formulation studies to the registration phase .
Common issues encountered are API chemical instability, API lack…
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Development of Child-Friendly Lisdexamfetamine Chewable Tablets Using Ion Exchange Resin as a…
Taste masking is critical to improving the compliance of pediatric oral dosage forms. However, it is challenging for extremely bitter lisdexamfetamine dimesylate (LDX) with a long half-life and given in large dose. The present study aims to develop an immediate-release, taste-masked lisdexamfetamine…
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Better performance with Pharma MMC – by Disruptive Pharma
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Better performance with Pharma MMC amorphous drug formulations offerings
Give existing products extended life and improved performance.
Facilitate novel drug development with one formulation from pre-clinical, though clinical and to commercial stage.…
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Layer by layer self-assembly for coating a nanosuspension to modify drug release and stability for…
Layer-by-layer (LbL) modification is an effective way to tune the properties of particles. However, the traditional LbL process involves repeated washing steps which are not compatible with nanoparticles with a partial solubility. In this work, we demonstrate the use of a titration method for…
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Ranking mAb–excipient interactions in biologics formulations by NMR spectroscopy and computational…
ABSTRACT
Excipients are added to biopharmaceutical formulations to enhance protein stability and enable the development of robust formulations with acceptable physicochemical properties, but the mechanism by which they confer stability is not fully understood. Here, we aimed to elucidate the…
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Core-Shell Structured PLGA Particles Having Highly Controllable Ketoprofen Drug Release
The non-steroid anti-inflammatory drug ketoprofen (KP) as a model molecule is encapsulated in different poly(lactide-co-glycolide) (PLGA) nanostructured particles, using Tween20 (TWEEN) and Pluronic F127 (PLUR) as stabilizers to demonstrate the design of a biocompatible colloidal carrier particles…
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SmartEx® Plus: a New Co-Processed Excipient for Oral Disintegration Tablets
SmartEx® Plus is an exciting new co-processed excipient that has been developed by Japanese chemical company Shin-Etsu to meet the increased demand for oral disintegration tablets (ODTs), with the added advantage that it offers excellent stability without compromising on disintegration time.
This…
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Neutralisation of SARS-CoV-2 by monoclonal antibody through dual targeting powder formulation
Neutralising monoclonal antibody (mAb) is an important weapon in our arsenal for combating respiratory viral infections. However, the effectiveness of neutralising mAb has been impeded by the rapid emergence of mutant variants. Early administration of broad-spectrum mAb with improved delivery…
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Chemical Analysis and Molecular Modelling of Cyclodextrin-Formulated Propofol and Its Sodium Salt to…
Propofol is a widely used general anesthetic in clinical practice, but its use is limited by its water-insoluble nature and associated pharmacokinetic and pharmacodynamic limitations. Therefore, researchers have been searching for alternative formulations to lipid emulsion to address the remaining…
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