ADM

CPHI worldwide opens its doors again. This year in Frankfurt at the Messe Frankfurt. In two weeks, from 1st to 3rd November, you can finally have a face-to-face chat with visitors and exhibitors again. As usual, InnoPack, P-MEC, FDF, ICSE and BioProduction will be held together with CPHI. The…
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Pea protein isolate (PPI)-maltodextrin (MD) conjugates were prepared by using controlled Maillard reaction at 90 °C in the solution state (wet-heating route). The degree of conjugation between PPI and MD was measured in terms of evolved colour, UV absorbance, and molecular weight change. Results…
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Understanding of the sweetness of an organic or inorganic substance is complex process and it is ingrained with the intricacies of psychological perception, molecular structure, chemical nature and environmental conditions e.g. pH, temperature, type of medium etc. Sucrose tastes sweet but when it is…
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The search for novel strategies to formulate bioactive molecules for topical administration is a matter of permanent interest in the pharmaceutical field. As a contribution, the present work deepens the bigels, i.e., matrix-in-matrix systems resulting from mixing a hydrogel and an organogel.…
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The present study aims to design and develop a nanoemulgel formulation of Tamoxifen citrate (TAM), a water-insoluble, potent anticancer drug, using the spontaneous emulsification method to improve topical delivery, achieve high accumulation at the tumour site, and spare the healthy tissues. The…
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Nanotechnologies such as nanoparticles are established components of new medical devices and pharmaceuticals. The use and distribution of these materials increases the requirement for standardized evaluation of possible adverse effects, starting with a general cytotoxicity screening. The Horizon…
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Cancer refers to a collection of diseases that have abnormal cell growth as their hallmark. This inability of cytotoxic agents to distinguish between rapidly dividing healthy cells andrapidly multiplying cancerous cells produces the most notorious adverse effects of cytotoxicanticancer agents. As an…
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Two widely applied enabling drug delivery approaches, self-nanoemulsifying drug delivery systems (SNEDDS) and amorphous solid dispersions (ASD), were combined, with the aim of enhancing physical stability, solubilization and absorption of the model drug ritonavir. Ritonavir was loaded at a…
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Long acting injectables (LAI) have received increased research and commercial interest due to their potential for improving treatment effectiveness and adherence for antipsychotic, antiviral and addiction treatments. A range of materials have been used to formulate LAI products, including lipids and…
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The aim of this work was to systematically study the effect of freeze-drying of bottom-up processed cilostazol nanosuspension on the particle size after redispersion. Several different cryoprotectants and concentrations were compared and the influence of processing variables such as freezing…
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