Asahi Kasei

Abstract Roller compaction is gaining importance in the pharmaceutical industry. This study evaluates the impact of ribbon milling conditions on properties of granules and compression mixtures and on drug release from hypromellose-based matrix tablets prepared with two different fillers. In the…
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ABSTRACT Background Novel delivery strategies are being explored since low bioavailability presents a challenge for medications like valsartan. Mucoadhesive drug delivery systems present a viable alternative by enhancing drug absorption and retention. Aim This study aimed to develop…
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Suppliers of pharmaceuticals and excipients face challenges in controlling technically unavoidable particles (TUPs) to prevent defects and protect brand reputation. Ceolus™,  Asahi Kasei´s microcrystalline cellulose (MCC) products demonstrate exceptionally low levels of TUPs thanks to their…
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Abstract The bitter drug, warfarin, has a narrow therapeutic index (NTI) and is used in paediatrics and geriatrics. The aim of this feasibility study was to formulate the taste-masked warfarin-containing pellets to be applicable for dose personalisation and to improve patient compliance, as well as…
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This poster was presented at the PBP World Meeting in Vienna 2024 by Asahi-Kasei INTRODUCTION It is known that the pressure, friction, heat, etc. applied during compression molding of some drugs causes crystal distortion and destabilization. When dealing with such kinds of substances,…
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Abstract Tablets are the most commonly used dosage form in the pharmaceutical industry, and their properties such as disintegration, dissolution, and portability are influenced by their strength. However, in industry, the mixing fraction of powders to obtain a tablet compact with sufficient…
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Introduction Using in tablet formulations microcrystalline cellulose (MCC) with plastic behaviour and calcium phosphate anhydrous (CaHPO4 ) with brittle behaviour under compaction is very popular in the pharmaceutical industry for achieving desirable structural-mechanical properties of tablets.…
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Introduction High-drug-loaded tablets and capsules are desirable and are manufactured using granulation as an additional step. Replacing batch wet granulation with twin-screw melt extruder as a continuous solventless process is gaining popularity. PEG 8000 being one of the most popular…
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Abstract Using microcrystalline cellulose (MCC) with plastic behaviour and calcium phosphate anhydrous (CaHPO4) with brittle behaviour under compaction is very popular in the pharmaceutical industry for achieving desirable structural–mechanical properties of tablet formulations. Thus, mixtures of…
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PRESS RELEASE February 27, 2024, Asahi Kasei Corp. Contributing to lower risk of potentially carcinogenic nitrosamine impurities in pharmaceuticals To contribute to reducing the risk of potentially carcinogenic nitrosamine impurities in pharmaceuticals and nutritional supplements, Asahi Kasei…
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